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LUPRON DEPOT-3 MONTH 22.5mg
Prostate and other male cancers
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Drug Name:

LUPRON DEPOT-3 MONTH 22.5mg Rx

Generic Name and Formulations:
Leuprolide acetate 22.5mg; depot susp for IM inj; preservative-free.

Company:
AbbVie

Therapeutic Use:

Indications for LUPRON DEPOT-3 MONTH 22.5mg:

Palliative treatment of advanced prostatic carcinoma.

Adult:

Give as single IM inj into gluteal area, anterior thigh or deltoid; rotate inj sites. 22.5mg once every 3 months (12 weeks). Do not split doses.

Children:

Not applicable.

Contraindications:

Pregnancy (Cat.X).

Warnings/Precautions:

Initial worsening of signs/symptoms (eg, bone pain, ureteral obstruction, spinal cord compression) may occur; monitor closely in metastatic vertebral lesions, urinary obstruction, hematuria. Monitor serum testosterone, PSA. Increased risk of diabetes, MI, sudden cardiac death, stroke; monitor blood glucose, HbA1c, and for signs/symptoms of CVD during therapy. Increased risk of convulsions in patients with history of seizures, epilepsy, cerebrovascular disorder, CNS anomalies or tumors. Risk of QT prolongation in long-term androgen deprivation therapy, congenital long QT syndrome, electrolyte abnormalities (correct and monitor), or CHF; consider monitoring ECGs. Instruct patient on correct self administration. Nursing mothers: not recommended.

See Also:

LUPRON DEPOT 7.5mg

LUPRON DEPOT-4 MONTH 30mg

LUPRON DEPOT-6 MONTH 45mg

Pharmacological Class:

GnRH analogue.

Interactions:

Concomitant antiarrhythmics may prolong the QT interval. Risk of seizures with concomitant SSRIs, bupropion, others.

Adverse Reactions:

Hot flashes/sweats, pain, GI disorders, edema, respiratory disorder, urinary disorders, inj site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue; tumor flare, hyperglycemia, convulsions, hypersensitivity.

How Supplied:

Depot kit—1 (prefilled dual-chamber syringe w. supplies)


Data provided by MPR.

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