Lenalidomide Plus Rituximab Active in MALT Lymphoma

Share this content:
Lenalidomide plus rituximab may be more effective for the treatment of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).
Lenalidomide plus rituximab may be more effective for the treatment of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).

Lenalidomide plus rituximab may be more effective for the treatment of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma) than lenalidomide alone, according to a study published in Blood.1

Rituximab and lenalidomide were previously shown to be active in hematologic malignancies. A previous study showed, however, that lenalidomide alone had a complete response rate of only 33% in MALT lymphoma.

For the phase 2 AGMT MALT-2 trial (ClinicalTrials.gov Identifier: NCT01611259), 46 patients with MALT lymphoma were enrolled and evaluated for treatment with lenalidomide plus rituximab.

The objective response rate with this treatment combination was 80%; the time to best response averaged 3.6 months. More than half of the patients achieved a complete response, and the 27-month progression-free survival was 91%.

No grade 4 non-hematologic adverse events were reported; common mild adverse events included musculoskeletal pain, fatigue, cough/respiratory infection, diarrhea, and vertigo. Grade 3-4 neutropenia occurred in 18.8% of patients.

RELATED: Study Affirms Activity of Nivolumab in Heavily Pretreated Classical Hodgkin Lymphoma

Lenalidomide plus rituximab, according to the study's authors, is a safe and efficacious treatment in MALT lymphoma, regardless of previous treatment and primary localization.

Reference

  1. Kiesewetter B, Willenbacher E, Willenbacher W, et al. A phase II study of rituximab plus lenalidomide for mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Blood. 2016 Nov 22. doi: 10.1182/blood-2016-06-720599 [Epub ahead of print]

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs