R-DexaBEAM Followed by High-Dose Therapy Effective as Salvage Therapy for Non-Hodgkin Lymphoma
the Cancer Therapy Advisor take:
According to a new study published in the British Journal of Haematology, researchers from University Medical School of the Johannes Gutenberg University Mainz in Mainz, Germany, have found that rituximab plus DexaBEAM (dexamethasone, carmustine, etoposide, cytarabine, melphalan) followed by high-dose therapy is an effective salvage therapy option for the treatment of patients with non-hodgkin lymphoma.
For the phase 2, multicenter study, researchers sought to investigate the effect of R-DexaBEAM followed by high-dose therapy on progression-free survival in patients with relapsed lymphoma. Patients were included if they were 18-65 years old, had an ECOG performance score of 0-2, and had relapsed/refractory B-cell non-hodgkin lymphoma.
Researchers enrolled 103 patients (55 with diffuse large B-cell lymphoma, 7 with mantle cell lymphoma, 5 with grade 3 follicular lymphoma, 29 with grade 1-2 follicular lymphoma, 6 with marginal zone lymphoma, and 1 with immunocytoma. Patients received R-Dexa-BEAM for two cycles followed by stem cell mobilization and high-dose therapy.
Results showed an overall response rate of 62% for those with aggressive non-hodgkin lymphoma and 78% for those with indolent non-Hodgkin lymphoma. The median progression-free survival was 0.83 years and 3.7 years for patients with aggressive disease and indolent disease, respectively.
Rituximab plus DexaBEAM followed by high-dose therapy is an effective salvage therapy option.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- A Vegan Diet and Cancer
- As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination
- Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes
- Ponatinib Tops Bosutinib for Third-Line Treatment of CML in a Comparative Analysis
- Duvelisib Delayed Progression in CLL/SLL: Study
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Prostate Cancer Drug Treatments
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Potential Diagnostic Tool Detects BCR-ABL1 mRNA in Chronic Myeloid Leukemia
- BTK Inhibitor Zanubrutinib Appears Promising in Waldenström Macroglobulinemia
- Carfilzomib Regimens Offer a Neuropathy-Sparing Approach in Multiple Myeloma, WM
- Apalutamide Does Not Diminish Quality of Life in Nonmetastatic Castration-Resistant Prostate Cancer
- Treatment Delays May Mean Worse Survival in Head and Neck Cancer