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Methyldopa/Hydrochlorothiazide Tablets
Hypertension
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Drug Name:

Methyldopa/Hydrochlorothiazide Tablets Rx

Generic Name and Formulations:
Methyldopa, hydrochlorothiazide; 250mg/15mg, 250mg/25mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Methyldopa/Hydrochlorothiazide Tablets:

Hypertension.

Adult:

Titrate individual components. Initially one 250mg/15mg tab 2–3 times daily or one 250mg/25mg tab 2 times daily.

Children:

Not recommended.

Contraindications:

Active hepatic disease. Anuria. Sulfonamide allergy. History of methyldopa-associated liver dysfunction. Concomitant MAOIs.

Warnings/Precautions:

History of hepatic dysfunction. Pheochromocytoma. Severe cerebrovascular or renal disease. SLE. Gout. Diabetes. Asthma. Edema. Dialysis. Postsympathectomy. Monitor blood, liver function, blood lipids, and electrolytes. Surgery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Central alpha agonist + diuretic.

Interactions:

MAOIs (see Contraindications). Alcohol, CNS depressants may increase orthostatic hypotension. May increase toxicity of diazoxide, digitalis and lithium. May antagonize oral hypoglycemics. Antagonized by NSAIDs, iron. May interfere with parathyroid tests.

Adverse Reactions:

Hemolytic anemia, fever, jaundice, hepatic necrosis, granulocytopenia, fluid or electrolyte imbalance, blurred vision, sedation, headache, asthenia, orthostatic hypotension, bradycardia, GI upset, rash, nasal congestion, hyperprolactinemia, arthralgia, positive Coomb's test.

Note:

Formerly known under the brand name Aldoril.

How Supplied:

Contact supplier.


Data provided by MPR.

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