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MINOCIN for INJECTION
Acne
Bacterial infections
Protozoal infections
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Drug Name:

MINOCIN for INJECTION

Generic Name and Formulations:
Minocycline 100mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains magnesium sulfate heptahydrate.

Company:
Melinta Therapeutics

Therapeutic Use:

Indications for MINOCIN for INJECTION:

Adjunct in severe acne.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN for INJECTION:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax due to B. anthracis.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

Indications for MINOCIN for INJECTION:

Adjunct in acute intestinal amebiasis.

Adult:

Give by IV infusion over 60 mins. Initially 200mg once, then 100mg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Children:

≤8yrs: not recommended. Give by IV infusion over 60 mins. >8yrs: Initially 4mg/kg once, then 2mg/kg every 12hrs; max 400mg daily. Renal impairment (CrCl <80mL/min): max 200mg/day.

Warnings/Precautions:

Monitor blood, renal, and hepatic function periodically. Discontinue if skin erythema, DRESS syndrome, or superinfection develops. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Renal impairment; monitor BUN and creatinine. Hepatic impairment. Avoid sun or UV light. IV: monitor magnesium levels in renal impairment; and monitor closely in patients with heart block or myocardial damage. Pregnancy, nursing mothers: not recommended.

See Also:

MINOCIN

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. Caution with other hepatotoxic drugs. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May antagonize oral contraceptives. Concomitant ergots or derivatives; increased risk of ergotism. May interfere with fluorescence test. IV (contains magnesium): avoid concomitant CNS depressants, neuromuscular blockers, cardiac glycosides.

Adverse Reactions:

Dizziness, GI upset, pruritus, increased BUN; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea, photosensitivity, hepatotoxicity, skin/hypersensitivity reactions (may be severe). IV: magnesium intoxication, inj site reactions.

How Supplied:

Caps—60; Single-use vials—1, 10

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