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MONODOX
Acne
Bacterial infections
Protozoal infections
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Drug Name:

MONODOX Rx

Generic Name and Formulations:
Doxycycline monohydrate 50mg, 75mg, 100mg; caps.

Company:
Aqua Pharmaceuticals

Therapeutic Use:

Indications for MONODOX:

Adjunct in severe acne.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12hrs or 50mg every 6hrs), then 100mg daily (as a single dose or 50mg every 12hrs).

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

How Supplied:

Caps 50mg, 75mg—100; 100mg—50, 250


Data provided by MPR.

Indications for MONODOX:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Alternative for selected infections when penicillin is contraindicated. Anthrax, including inhalational anthrax (postexposure).

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12hrs or 50mg every 6hrs), then 100mg daily (as a single dose or 50mg every 12hrs); if severe infections (eg, chronic UTI): 100mg every 12 hours. Streptococcal infections: treat for 10 days. Uncomplicated urethral, endocervical, rectal infection, or nongonococcal urethritis (NGU): 100mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg single dose followed by a second 300mg dose 1hr later. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Syphilis (primary/secondary): 300mg/day in divided doses for at least 10 days. Anthrax: 100mg twice daily for 60 days.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose. Anthrax (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

Note:

See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.

How Supplied:

Caps 50mg, 75mg—100; 100mg—50, 250


Data provided by MPR.

Indications for MONODOX:

Adjunct in acute intestinal amebiasis.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12hrs or 50mg every 6hrs), then 100mg daily (as a single dose or 50mg every 12hrs); if severe infections: 100mg every 12hrs.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

Note:

See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.

How Supplied:

Caps 50mg, 75mg—100; 100mg—50, 250


Data provided by MPR.

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