Early Treatment Beneficial for Smoldering Multiple Myeloma

Share this content:
Treatment Beneficial in Smoldering Multiple Myeloma
Treatment Beneficial in Smoldering Multiple Myeloma

(HealthDay News) -- For patients with smoldering multiple myeloma, treatment with lenalidomide plus dexamethasone correlates with delayed progression and improved survival, according to a study published in the Aug. 1 issue of the New England Journal of Medicine.

María-Victoria Mateos, M.D., Ph.D., from the Hospital Universitario de Salamanca in Spain, and colleagues conducted an open-label, phase 3 trial in which 119 patients with high-risk smoldering myeloma were randomized to treatment or observation. Treatment included an induction regimen (nine cycles of lenalidomide plus dexamethasone) followed by maintenance lenalidomide for 2 years.

After a median follow-up of 40 months, the researchers found that the median time to progression was significantly longer in the treatment group (median not reached) versus the observation group (21 months; hazard ratio for progression, 0.18). The treatment group also had a significantly higher 3-year survival rate (94% versus 80%; hazard ratio for death, 0.31). In the treatment group, a partial response or better was achieved by 79% of patients after the induction phase and by 90% during the maintenance phase.

"In conclusion, this randomized, phase 3 trial showed that early treatment with lenalidomide and dexamethasone, followed by maintenance therapy with lenalidomide, in patients with high-risk smoldering multiple myeloma significantly delayed the time to progression to symptomatic disease and resulted in an overall survival benefit," the authors write.

The study was funded by Celgene, the manufacturer of lenalidomide.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs