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NEUPRO
Parkinsonism
Restless legs syndrome
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Drug Name:

NEUPRO Rx

Generic Name and Formulations:
Rotigotine 1mg/24hrs, 2mg/24hrs, 3mg/24hrs, 4mg/24hrs, 6mg/24hrs, 8mg/24hrs; transdermal patch; contains sulfite.

Company:
UCB Inc.

Therapeutic Use:

Indications for NEUPRO:

Idiopathic Parkinson's disease.

Adult:

Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Early-stage: initially 2mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 6mg/24hrs once daily. Advanced-stage: initially 4mg/24hrs patch once daily; may increase weekly by 2mg/24hrs if needed; max 8mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 2mg/24hrs every other day.

Children:

Not established.

Warnings/Precautions:

Avoid external heat sources. Remove patch before cardioversion, MRI. Sleep disorders; consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if compulsive behaviors develop. Asthma. Pre-existing dyskinesia. Severe hepatic impairment. Monitor for melanoma. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Dopamine agonist (non-ergot).

Interactions:

Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.

Adverse Reactions:

Nausea, vomiting, somnolence (may be sudden), application site reactions, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation.

Metabolism:

Hepatic.

Elimination:

Renal, fecal.

Generic Availability:

NO

How Supplied:

Patches—30


Data provided by MPR.

Indications for NEUPRO:

Moderate-to-severe primary restless legs syndrome (RLS).

Adult:

Apply to clean, dry, intact skin on abdomen, thigh, hip, flank, shoulder, or upper arm. Initially 1mg/24hrs patch once daily; may increase weekly by 1mg/24hrs if needed; max 3mg/24hrs once daily. Rotate application site (allow 14 days before reapplying to same site). Shave site at least 3 days before application if hairy. Avoid abrupt cessation; reduce by 1mg/24hrs every other day.

Children:

Not established.

Warnings/Precautions:

Avoid external heat sources. Remove patch before cardioversion, MRI. Sleep disorders; consider discontinuing if excessive daytime sleepiness or falling asleep during activities occurs. Psychotic disorder. Increased risk of symptomatic hypotension; monitor BP esp. during dose adjustments. Cardiovascular disease. Conditions aggravated by fluid retention (eg, CHF, renal insufficiency); monitor for weight gain. Consider dose reduction or discontinuation if compulsive behaviors develop. Asthma. Pre-existing dyskinesia. Severe hepatic impairment. Monitor for melanoma. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacological Class:

Dopamine agonist (non-ergot).

Interactions:

Caution with concomitant alcohol, sedating drugs or other CNS depressants (eg, benzodiazepines, antipsychotics, antidepressants). May be antagonized by metoclopramide, antipsychotics.

Adverse Reactions:

Nausea, vomiting, somnolence (may be sudden), application site reactions, headache, dizziness, anorexia, hyperhidrosis, insomnia, peripheral edema, dyskinesia; orthostatic hypotension, syncope, hallucinations, psychotic-like behavior, intense urges/compulsions, hypertension, heart rate elevation, augmentation/rebound of RLS symptoms.

Metabolism:

Hepatic.

Elimination:

Renal, fecal.

Generic Availability:

NO

How Supplied:

Patches—30


Data provided by MPR.

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