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In Mice, Lithium Shown to Reverse Dysfunction Related to Brain Tumor Compression

In Mice, Lithium Shown to Reverse Dysfunction Related to Brain Tumor Compression

The neuronal loss and neurological dysfunction caused by solid stress from brain tumors was reversed by lithium in mice models.

Immunotherapy Plus Chemotherapy May Turn Cold Tumors Hot

Immunotherapy Plus Chemotherapy May Turn Cold Tumors Hot

Immune checkpoint blockade combined with chemotherapy may sensitize "cold" tumors to immunotherapy and lead to enhanced responses.

Spending on Medical DTC Advertising Increased Dramatically Over the Past 20 Years

Spending on Medical DTC Advertising Increased Dramatically Over the Past 20 Years

The spend on medical marketing in the United States has dramatically grown over a 20-year span, but drug marketing as a proportion of total US drug spending decreased.

Effect of Chemotherapy on Prometastatic Extracellular Vesicles Warrants Further Research

Effect of Chemotherapy on Prometastatic Extracellular Vesicles Warrants Further Research

Breast cancer models showed certain neoadjuvant chemotherapy promoted prometastatic behavior.

Liquid Biopsy of Cerebrospinal Fluid Provides Genomic Info on Brain Tumors

Liquid Biopsy of Cerebrospinal Fluid Provides Genomic Info on Brain Tumors

Clinical application of cerebrospinal fluid ctDNA analysis remains unclear.

Lifestyle Factors Accelerated Age-Related Remodeling of Esophageal Tissue

Lifestyle Factors Accelerated Age-Related Remodeling of Esophageal Tissue

Smoking and drinking were related to changes in the esophageal epithelium.

Primary End Point Not Met in Trial Testing Nivolumab Monotherapy for DLBCL

Primary End Point Not Met in Trial Testing Nivolumab Monotherapy for DLBCL

Nivolumab monotherapy for R/R DLBCL failed to confer improved objective response rates, but did produce durable responses in 3 individuals.

Chemoimmunotherapy Regimen Confers Benefit in Double Expressor DLBCL

Chemoimmunotherapy Regimen Confers Benefit in Double Expressor DLBCL

Patients younger than 65 with double expressor diffuse large B-cell lymphoma had better outcomes with dose-adjusted EPOCH plus rituximab than R-CHOP.

Imatinib Found to Be Effective in Unresectable Dermatofibrosarcoma Protuberans

Imatinib Found to Be Effective in Unresectable Dermatofibrosarcoma Protuberans

Eight in 10 patients with DFSP saw a clinical benefit from treatment with imatinib.

Specific T Cells Play Key Role in Melanoma-Immune Equilibrium

Specific T Cells Play Key Role in Melanoma-Immune Equilibrium

Tissue-resident memory CD8+ T cells helped suppress melanoma in an animal study.

Single-Cell Examination Can Provide Insights into Tumor Microenvironment

Single-Cell Examination Can Provide Insights into Tumor Microenvironment

Cellular examination of follicular lymphoma reveals malignant B-cell types, coexpression of T-cell immune checkpoints.

Takeda to Collaborate With MSKCC on CAR-T Therapies for Multiple Myeloma

Takeda to Collaborate With MSKCC on CAR-T Therapies for Multiple Myeloma

Takeda will work with Memorial Sloan Kettering Cancer Center to develop CAR-T therapies for multiple myeloma.

Depth of Response Translates Into Real-World Benefit in Multiple Myeloma

Depth of Response Translates Into Real-World Benefit in Multiple Myeloma

Depth of response corresponded to overall survival and time to next treatment in real-world patients with relapsed/refractory multiple myeloma.

MSI-H/dMMR Is Clinically Meaningful, Despite Being Uncommon in Prostate Cancer

MSI-H/dMMR Is Clinically Meaningful, Despite Being Uncommon in Prostate Cancer

Biomarkers of PD-1/PD-L1 checkpoint inhibitor response in prostate cancer could help stratify patients by response.

Pyrotinib Shows Activity in HER2-Positive Non-Small Cell Lung Cancer

Pyrotinib Shows Activity in HER2-Positive Non-Small Cell Lung Cancer

Pyrotinib showed activity in HER2-positive non-small cell lung cancer, both in preclinical experiments and in patients enrolled in a phase 2 trial.

Overactive Bladder Linked to Prostate Cancer ADT

Overactive Bladder Linked to Prostate Cancer ADT

Compared with men receiving androgen deprivation therapy for prostate cancer, healthy men had a 98% decreased risk of overactive bladder, study finds.

Prostate Cancer Possibly Linked to Zinc Intake

Prostate Cancer Possibly Linked to Zinc Intake

In a Spanish study, the highest vs lowest tertile of dietary zinc intake was associated with a significant 66% increased relative risk of low-grade prostate cancer.

Surgical Practices May Explain International Survival Differences in Cancer Treatment

Surgical Practices May Explain International Survival Differences in Cancer Treatment

Overall, patient survival was not associated with surgical technique.

New Epigenetic Cervical Cancer Test Outperforms Pap and HPV Testing

New Epigenetic Cervical Cancer Test Outperforms Pap and HPV Testing

Epigenetic aberrations, as opposed to DNA mutations themselves, might play a more important role in the progression of many malignancies.

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer

Study results suggest a new combination regimen could become the standard of care for some patients.

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