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Study Finds Real-World Data on Cardiac Toxicity of Trabectedin May Be Limited

Study Finds Real-World Data on Cardiac Toxicity of Trabectedin May Be Limited

Researchers observed increased real-world incidence of cardiomyopathy in patients treated with trabectedin compared with that seen in the phase 3 study of the drug.

POT1 Revealed as a Sarcoma Predisposition Gene

POT1 Revealed as a Sarcoma Predisposition Gene

Australian researchers identified the gene using whole-genome sequencing in patients enrolled in the International Sarcoma Kindred Study.

IMRT Linked to Fewer Instances of Local Recurrence in Sarcoma: A Long-Term Follow-Up

IMRT Linked to Fewer Instances of Local Recurrence in Sarcoma: A Long-Term Follow-Up

But, there was no difference in DFS, DMFS, or OS between the 2 treatment subtypes at 5 years following the conclusion of the original study.

Study Adds More Evidence to Support Active Surveillance as the Standard of Care for Certain Desmoid Tumors

Study Adds More Evidence to Support Active Surveillance as the Standard of Care for Certain Desmoid Tumors

Experts embrace the "less is more" approach to guide treatment decisions in primary sporadic desmoid tumors.

Dosing Schedule May Be Key to Optimal Administration of Milademetan for Sarcoma Subtype

Dosing Schedule May Be Key to Optimal Administration of Milademetan for Sarcoma Subtype

The switch from a continuous to an intermittent dosing schedule appeared to cut the occurrence of thrombocytopenia in half.

Phase 2 Trial of Abemaciclib in Dedifferentiated Liposarcoma Meets Primary End Point

Phase 2 Trial of Abemaciclib in Dedifferentiated Liposarcoma Meets Primary End Point

A subset of patients experienced sustained clinical benefit and at least some objective tumor response.

Mouse-Dog-Human Preclinical Cancer Model for Osteosarcoma Proposed

Mouse-Dog-Human Preclinical Cancer Model for Osteosarcoma Proposed

Researchers suggested the use of comparative oncology to identify novel therapies that could have clinical applications in osteosarcoma.

ALK Fusions Thought to Be Oncogenic Drivers in Some Leiomyosarcomas

ALK Fusions Thought to Be Oncogenic Drivers in Some Leiomyosarcomas

Analysis of transcriptomic data revealed that a subset of patients with these smooth muscle sarcomas have ALK fusions that retain targetable ALK kinase domains.

Unfavorable Prognosis in Sarcoma May Be Linked to Tumor Involvement of Fascia

Unfavorable Prognosis in Sarcoma May Be Linked to Tumor Involvement of Fascia

Patients with fascia-infiltrating sarcoma appeared to have worse survival that those who had either strict superficial or deep soft tissue sarcomas.

H. pylori Eradication Did Not Result in Platelet Recovery for All Chronic ITP Cases

H. pylori Eradication Did Not Result in Platelet Recovery for All Chronic ITP Cases

The patients who did respond following the eradication of infection, however, had responses up to 1 year.

Posttransplant AML Relapse Linked to Pathways Influencing Immune Function

Posttransplant AML Relapse Linked to Pathways Influencing Immune Function

There were no previously unknown AML-specific mutations or structural variations in immune-related genes among patients with AML who had undergone transplant.

Immunotherapy Combo in Head and Neck Cancer Shows Activity in Phase 2 Trial

Immunotherapy Combo in Head and Neck Cancer Shows Activity in Phase 2 Trial

Durvalumab with or without tremelimumab deemed safe and effective in patients with recurrent or metastatic head and neck squamous cell carcinoma.

Prototype Intervention Increased Adherence to TKIs in CML

Prototype Intervention Increased Adherence to TKIs in CML

A prototype intervention increased adherence to tyrosine kinase inhibitor therapy in some patients with chronic myeloid leukemia.

Higher Sensitivity With 1-View Digital Breast Tomosynthesis for Breast Cancer Detection

Higher Sensitivity With 1-View Digital Breast Tomosynthesis for Breast Cancer Detection

One-view digital breast tomosynthesis with a reduced compression force detected breast cancer with higher sensitivity and lower specificity than 2-view digital mammography.

Trial Identifies Marker for Response to Immunotherapy in Esophageal Cancer

Trial Identifies Marker for Response to Immunotherapy in Esophageal Cancer

A clinical trial found a potential marker to identify the patients with advanced esophageal squamous cell carcinoma who were most likely to respond to nivolumab.

HER2 Amplification in Brain Metastases May Be Relatively Common in GI Cancer

HER2 Amplification in Brain Metastases May Be Relatively Common in GI Cancer

Brain metastases were HER2-positive in nearly one-third of patients with gastrointestinal primary malignancies, suggesting molecular testing may be prudent.

Long-Term Surgical Outcomes for Rectal Cancer Survivors Elucidated in Study

Long-Term Surgical Outcomes for Rectal Cancer Survivors Elucidated in Study

Participant characteristics were similar between surgical treatment groups.

Patient Evaluation of Quality in GI Cancer Surgery

Patient Evaluation of Quality in GI Cancer Surgery

Patient-reported quality measures, collected from those who underwent surgery for GI cancer, offered clinicians valuable insight into care management.

Study Found Worse Survival for Patients with Familial Colorectal Cancer Type X

Study Found Worse Survival for Patients with Familial Colorectal Cancer Type X

In patients who developed CRC, those who had familial CRC type X were found to have worse survival outcomes than those who had Lynch syndrome.

BRCA1 Mutation Observed to Confer Heightened Risk of Colorectal Cancer

BRCA1 Mutation Observed to Confer Heightened Risk of Colorectal Cancer

A systematic review and meta-analysis determined that carriers for a mutation to BRCA1, but not BRCA2, have an increased risk of colorectal cancer.

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