Oropharyngeal Cancer

As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination

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Oropharyngeal cancers have become the most common HPV-associated malignancies in the US, where the rate of vaccination against HPV lags compared with other countries.

Phase 2 Study of ADXS 11-001 Vaccination in HPV-positive Oropharyngeal Squamous Cell Carcinoma

Phase 2 Study of ADXS 11-001 Vaccination in HPV-positive Oropharyngeal Squamous Cell Carcinoma

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Researchers are evaluating whether ADXS 11-001 vaccination prior to transoral surgery will improve outcomes for patients with HPV-positive oropharyngeal cancer.

Phase 1b/2 Study of DPX-E7 + Cyclophosphamide in HPV-positive Cancers

Phase 1b/2 Study of DPX-E7 + Cyclophosphamide in HPV-positive Cancers

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Researchers are evaluating whether DPX-E7 vaccination is safe and will improve outcomes among patients with HPV-positive head and neck, cervical, or anal cancer.

TORS May Improve Swallowing Function in Patients With Oropharyngeal Cancer

TORS May Improve Swallowing Function in Patients With Oropharyngeal Cancer

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Findings suggest that TORS is a promising strategy for improving swallowing function in patients with OPSCC, without compromising disease-free survival.

New Staging System for HPV-positive Oropharyngeal Cancer Proposed

New Staging System for HPV-positive Oropharyngeal Cancer Proposed

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The ICON-S developed a TNM classification specific to human papillomavirus (HPV)-related oropharyngeal cancer.

HPV-16 in Oral Cavity Associated With Increased Risk of Oropharyngeal Squamous Cell Carcinoma

HPV-16 in Oral Cavity Associated With Increased Risk of Oropharyngeal Squamous Cell Carcinoma

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Detection of human papillomavirus (HPV)-16 in the oral cavity may be associated with 22-times increased risk of oropharyngeal squamous cell carcinoma.

HPV16+ Patients With Oropharyngeal Squamous Cell Cancer Survive Longer Than HPV- Patients

HPV16+ Patients With Oropharyngeal Squamous Cell Cancer Survive Longer Than HPV- Patients

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Human papillomavirus 16 (HPV16)-positive patients with oropharyngeal squamous cell cancer (OPSCC) survive longer than HPV-negative patients.

Veterans May Face Poorer Oral, Throat Cancer Outcomes

Veterans May Face Poorer Oral, Throat Cancer Outcomes

In veterans, oropharyngeal squamous cell carcinoma (SCC) is associated with traditional carcinogens and poor clinical outcomes.

HPV16 DNA Rinse Post Treatment Could Predict Recurrence

HPV16 DNA Rinse Post Treatment Could Predict Recurrence

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Human papillomavirus (HPV) type 16 DNA in oral rinses is common at diagnosis, but rare after treatment for HPV oropharyngeal carcinoma (OPC).

Cost Burdens on Patients Older than 66 with Oral Cavity, Pharyngeal Cancers

Cost Burdens on Patients Older than 66 with Oral Cavity, Pharyngeal Cancers

Several factors associated with the burdensome Medicare cost of oral and pharyngeal cancer in older patients.

In Teen Boys, HPV4 Vaccine Cost-Effective for Oropharyngeal Prevention

In Teen Boys, HPV4 Vaccine Cost-Effective for Oropharyngeal Prevention

The quadrivalent human papillomavirus (HPV4) vaccine appears to be cost-effective for the prevention of oropharyngeal cancer (OPC).

Treatment Deintensification for HPV-Associated Oropharynx Cancer

Treatment Deintensification for HPV-Associated Oropharynx Cancer

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The Eastern Cooperative Oncology Group (ECOG) conducted a trial to investigate whether treatment deintensification was feasible in patients with HPV-associated cancer.

Challenges in Oropharyngeal Cancer Identified

Challenges in Oropharyngeal Cancer Identified

Mixed views in relation to explaining causal role of human papillomavirus (HPV) in oropharyngeal cancer.

Cannabinoids May Provide Pain Relief in Oral Cancer

Cannabinoids May Provide Pain Relief in Oral Cancer

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Oral malignancies can be associated with increased pain, but current research suggests that a cannabis-based spray may reduce this morbidity.

HPV Status Linked to Survival in Oropharynx Cancer

HPV Status Linked to Survival in Oropharynx Cancer

For patients with oropharynx cancer, HPV positivity is associated with improved survival after disease progression.

Head and Neck Cancer Knowledge Low Among US Adults

Head and Neck Cancer Knowledge Low Among US Adults

Two-thirds of surveyed adults reported being not very or not at all knowledgeable about head and neck cancer.

Reduced-dose Radiation Safe for Certain Patients with Low-risk HPV-positive Oropharyngeal Cancer

Reduced-dose Radiation Safe for Certain Patients with Low-risk HPV-positive Oropharyngeal Cancer

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CHICAGO, IL—Reduced-dose intensity-modulated radiotherapy after complete clinical responses to induction chemotherapy for operable stage III/IVA, human papillomavirus (HPV)-positive head and neck cancer appears to be safe and might improve patients' quality of life.

Gabapentin Has Benefits in Oropharyngeal Cancer

Gabapentin Has Benefits in Oropharyngeal Cancer

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ANAHEIM, CALIFORNIA—Among oropharyngeal patients receiving radiotherapy, gabapentin improved pain management and reduced weight loss, which potentially prevents the need for placement of a gastrostomy tube.

Oncogenic Oral HPV Prevalent in HPV+ Oropharyngeal Cancer

Oncogenic Oral HPV Prevalent in HPV+ Oropharyngeal Cancer

Oral HPV, HPV16 DNA commonly detected in patients with oropharyngeal cancer, but not their partners.

Before HPV Vaccine, Most Oropharyngeal Cancers Were HPV+

Before HPV Vaccine, Most Oropharyngeal Cancers Were HPV+

Most oropharyngeal cancers in the United States diagnosed between 1995 and 2005 were positive for human papillomavirus, specifically HPV 16 or 18.

ID'ing Different First Symptoms in Patients With Two Types of OPSCC

ID'ing Different First Symptoms in Patients With Two Types of OPSCC

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Patients with HPV-positive OPSCC report different symptoms than those with HPV-negative OPSCC, which may have an effect on how early the disease is diagnosed.

Oropharyngeal Cancer Incidence Is Increasing

Oropharyngeal Cancer Incidence Is Increasing

From 1973 to 2009, the incidence of oropharyngeal squamous cell carcinoma (OPSCC) increased in patients younger than 45 years.

Cancer Deaths Down in the US

Cancer Deaths Down in the US

Death rates from cancer continue to decline in the United States

Insufficient Evidence to Support Primary Care Oral Cancer Screening

Insufficient Evidence to Support Primary Care Oral Cancer Screening

There is currently insufficient evidence to weigh the benefits and harms of PCP screening of asymptomatic adults for oral cancer.

Oropharyngeal Cancer Up in Young Patients

Oropharyngeal Cancer Up in Young Patients

Head and neck cancers have increased 60% since 1973.

HPV Antibodies Correlated with Oropharyngeal Cancer

HPV Antibodies Correlated with Oropharyngeal Cancer

In plasma samples obtained prior to diagnosis, the presence of human papillomavirus type 16 E6 antibodies was more likely to be detected in patients with oropharyngeal cancer than in controls.

HPV-Associated Oropharyngeal Cancer: A Growing Dilemma

HPV-Associated Oropharyngeal Cancer: A Growing Dilemma

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The incidence of HPV-negative oropharyngeal cancers (OPC) is in decline, but rates of HPV-positive OPC are increasing with no sign of abating.

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