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Penicillin G Sodium for Injection
Bacterial infections
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Drug Name:

Penicillin G Sodium for Injection Rx

Generic Name and Formulations:
Penicillin G sodium 5million Units/mL; pwd for IM inj or continuous IV drip after reconstitution; contains sodium 1.68mEq per million Units.


Therapeutic Use:

Indications for Penicillin G Sodium for Injection:

Susceptible severe infections where rapid and high penicillin levels are required (see literature).

Adults and Children:

Bacteremia, pneumonia, endocarditis, pericarditis, empyema, meningitis, other severe infections (due to streptococci, pneumococci, staphylococci): minimum of 5million Units per day. Syphilis: dosage and duration determined by age of patient and stage of disease. Gonorrheal endocarditis and arthritis: minimum 5million Units per day. Meningococcal meningitis: 1–2million Units IM every 2 hours, or continuous IV drip of 20–30million Units/day. Actinomycosis: 1–6million Units/day for cervicofacial cases; 10–20million Units/day for thoracic and abdominal disease. Clostridial infections: 20million Units/day as adjunctive therapy to antitoxin. Fusospirochetal infections: 5–10million Units/day. Rat-bite fever: 12–15million Units/day for 3–4 weeks. Listeria infections: Neonates: 500,000–1million Units/day. Adults with meningitis: 15–20million Units/day for 2 weeks. Adults with endocarditis: 15–20million Units/day for 4 weeks. Pasteurella infections: Bacteremia and meningitis: 4–6million Units/day for 2 weeks. Ersipeloid endocarditis: 2–20million Units/day for 4–6 weeks. Gram-negative bacteremia: 20–80million Units/day. Diphtheria (carrier state): 300,000–400,000 Units/day in divided doses for 10–12 days. Anthrax: a minimum of 5million Units/day in divided doses until cure is effected.


Cephalosporin, imipenem, or other allergy: not recommended. Asthma. Electrolyte imbalance possible with rapid IV infusion; infuse slowly and monitor electrolytes frequently. Sodium-restricted. Monitor renal, hepatic and hematopoietic function with long-term therapy. Newborns. Infants. Pregnancy (Cat.B). Nursing mothers.

Pharmacological Class:



Bacteriostatic antibiotics (eg, erythromycin, tetracycline) may diminish bactericidal effects. Potentiated by probenecid. May cause positive Coombs test, false positive reactions to Clinitest, Benedict's solution or Fehling's solution.

Adverse Reactions:

Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions.

How Supplied:


Data provided by MPR.

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