Men with Low-Risk Prostate Cancer Face Lower All-Cause Mortality vs. Cancer-Free Men

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the Cancer Therapy Advisor take:

Men with low-risk prostate cancer (PCa) face lower all-cause mortality compared to PCa-free men due to lower cardiovascular mortality.

Additionally, men with intermediate or high risk face substantial death risk regardless of Charlson comorbidity index (CCI).

These results were part of a recent study published in BJU International which looked at patient data gathered from PCBase Sweden. Mieke van Hemelrijck, PHD, and fellow researchers at King’s College London in the UK observed 57,187 men diagnosed with localized PCa between 1997 to 2009 as well as 114,374 age- and county-matched PCa-free control men.

They found that in men with low-risk PCa, all-cause mortality after 10 years was 18 percent compared to corresponding men without PCa who were at 21 percent, with 31 percent of patients dying from CVD compared to 37 percent, respectively.

In low-risk men, PCa was the third most common cause of death after cardiovascular disease and other cancers. In men with intermediate and high-risk localized PCa, their disease was the most common cause of death.

Neal D. Shore, MD, FACS, sits down to discuss PROSTVAC targeted immunotherapy for prostate cancer.
Men with low-risk PCa face lower all-cause mortality compared to PCa-free men.
In this study, authors want to detail the distribution of causes of death for localised prostate cancer (PCa). Men with low-risk PCa had lower all-cause mortality than PCa-free men due to lower cardiovascular mortality, driven by early detection selection.

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