Continuing Docetaxel Therapy May Improve Survival in Prostate Cancer

Share this content:
For patients with metastatic castration-resistant prostate cancer, 8 cycles of docetaxel may improve superior overall survival.
For patients with metastatic castration-resistant prostate cancer, 8 cycles of docetaxel may improve superior overall survival.

For patients with metastatic castration-resistant prostate cancer (mCRPC), 8 cycles of docetaxel, in contrast with 6 cycles, may improve superior overall survival, according to a post hoc analysis published in JAMA Oncology.1

This international, randomized, phase 3 Mainsail trail evaluated the efficacy and safety of docetaxel, prednisone, and lenalidomide (DPL) versus docetaxel, prednisone, and placebo (DP), among 1059 patients with mCRPC, until disease progression or unacceptable toxicity.

Median overall in patients treated with DPL was inferior to that of those in the DP arm, and was associated with greater incidence of adverse events.

Increased toxicity in the DPL arm resulted in the receipt of fewer docetaxel cycles (median, 6 cycles versus 8 cycles). Researchers investigated whether the number of docetaxel cycles administered affected the extent of clinical benefit.

Treatment with 8 cycles or more of docetaxel was associated with superior overall survival (hazard ratio, 1.909; 95% CI, 1.660-2.194; P < .001), regardless of whether patients received lenalidomide (hazard ratio, 1.060; 95% CI, 0.924-1.215; P = .41).

RELATED: USPSTF Recommendations Linked With Decrease in Prostate Cancer Incidence Rates

Patients who received more than 10 cycles had a median overall survival of 33.0 months, compared with 26.9 months for those who received 8 to 10 cycles, and 22.8 months for patients who received only 5 to 7 cycles (P < .001).              

Reference

  1. de Morree ES, Vogelzang NJ, Petrylak DP, et al. Association of survival benefit with docetaxel in prostate cancer and total number of cycles administered. JAMA Oncol. 2016 Aug 25. doi: 10.1001/jamaoncol.2016.3000 [Epub ahead of print]

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs