Signaling in Prostate Tumors Indicates Responsiveness

This article originally appeared here.
Share this content:
Signaling in Prostate Tumors Indicates Responsiveness
Signaling in Prostate Tumors Indicates Responsiveness

(HealthDay News) -- A test of the androgen responsiveness of circulating tumor cells in men with metastatic prostate cancer before and after androgen-deprivation therapy may help determine the best subsequent treatment, according to a study published online Oct. 23 in Cancer Discovery.

David T. Miyamoto, M.D., Ph.D., from the Massachusetts General Hospital Cancer Center in Charlestown, and colleagues measured androgen receptor signaling in circulating tumor cells from 25 men with metastatic prostate cancer before and after treatment.

The researchers found that androgen receptor signaling was predominantly on in untreated patients, while signaling was heterogeneous (androgen receptor-on, androgen receptor-off, and androgen receptor-mixed) in treated patients with castration-resistant prostate cancer. First-line androgen deprivation therapy led to a profound switch in signaling from on to off, while secondary treatment in castration-resistant cancer led to various responses. Patients whose tumor androgen receptor signaling remained on or partially on despite treatment with abiraterone acetate had worse treatment outcomes.

"Acquired resistance to first-line hormonal therapy in prostate cancer is heterogeneous in the extent of androgen receptor pathway reactivation," Miyamoto and colleagues conclude. "Measurement of pre- and post-treatment androgen receptor signaling within circulating tumor cells may help target such treatments to patients most likely to respond to second-line therapies."

One author disclosed ownership interest and is a consultant/advisor to BZL Biologics.


Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs