Soy Doesn't Reduce Prostate Cancer Recurrence

This article originally appeared here.
Share this content:
Soy Supplement Doesn't Cut Prostate Cancer Recurrence
Soy Supplement Doesn't Cut Prostate Cancer Recurrence

(HealthDay News) -- For men at high risk of biochemical recurrence after radical prostatectomy, daily consumption of a soy protein supplement is not associated with a reduction in the risk of recurrence, according to a study published in the July 10 issue of the Journal of the American Medical Association.

Maarten C. Bosland, D.V.Sc., Ph.D., from the University of Illinois at Chicago, and colleagues examined whether daily consumption of a soy protein isolate supplement for 2 years is associated with a reduction in the rate of biochemical recurrence of prostate cancer. Participants included 177 men at high risk of recurrence after radical prostatectomy for prostate cancer who were randomized to receive a daily serving of a beverage powder containing 20 g of protein in the form of soy protein isolate (87 men) or calcium caseinate (placebo; 90 men).

Following lack of treatment effects at a planned interim analysis, the trial was stopped early. The researchers found that 28.3% of participants developed biochemical recurrence within 2 years of entering the trial. Within the intervention and placebo groups, recurrence was 27.2% and 29.5%, respectively, with a hazard ratio for active treatment of 0.96 (log rank P = 0.89). There were no supplementation-related adverse events recorded, and adherence was more than 90%.

"This randomized clinical trial demonstrated that development of biochemical recurrence of prostate cancer after radical prostatectomy was not reduced or delayed by daily consumption of a 20-g soy protein isolate supplement in men at high risk of recurrence, but the intervention appeared safe and was well tolerated," the authors write.

One author disclosed financial ties to the pharmaceutical and biotechnology industries.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs