Tadalafil Doesn't Prevent Post-Radiotherapy ED in Prostate Cancer

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Tadalafil Doesn't Prevent Post-Radiotherapy ED in Prostate Cancer
Tadalafil Doesn't Prevent Post-Radiotherapy ED in Prostate Cancer

(HealthDay News) — Among men receiving radiotherapy for prostate cancer, daily use of tadalafil is not more effective than placebo in preventing erectile dysfunction, according to research published in the April 2 issue of the Journal of the American Medical Association.

Thomas M. Pisansky, MD, of the Mayo Clinic in Rochester, Minn., and colleagues randomly assigned men undergoing external radiotherapy (63%) or brachytherapy (37%) for prostate cancer to either tadalafil (n = 121) or placebo (n = 121) for 24 weeks.

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The researchers found that, between weeks 28 and 30, 79% (95% confidence interval [CI], 70%-88%) of the tadalafil group and 74% (95% CI, 63%-85%) of the placebo group retained erectile function (P = 0.49). At 1 year, no significant difference was observed between the groups. No significant difference was observed between the groups in overall sexual function or satisfaction.

Partners of men receiving tadalafil did not report a significant effect on sexual satisfaction. Neither participants nor partners reported significant improvement in marital adjustment with the use of tadalafil.

"Among men undergoing radiotherapy for prostate cancer, daily use of tadalafil compared with placebo did not result in improved erectile function," the researchers wrote.

Eli Lilly partially funded the study and supplied the study drug and placebo.

Reference

    Pisansky TM, Pugh SL, Greenberg RE, et al. Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer: The Radiation Therapy Oncology Group [0831] Randomized Clinical Trial. JAMA. 2014;311(13):1300-1307.

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