Vitamin D Deficiency May Raise Aggressive Prostate Cancer Risk

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Vitamin D Deficiency May Raise Aggressive Prostate Cancer Risk
Vitamin D Deficiency May Raise Aggressive Prostate Cancer Risk

(HealthDay News) -- Vitamin D levels appear to be associated with first prostate biopsy outcomes, according to research published in the May 1 issue of Clinical Cancer Research.

Adam B. Murphy, MD, of Northwestern University in Chicago, and colleagues analyzed data from 667 men, aged 40 to 79 years, to assess the association between serum 25-hydroxyvitamin D (25[OH]D) levels and outcomes of first prostate biopsy.

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The researchers found that, among European-American men, 25(OH)D less than 12 ng/mL was associated with Gleason score ≥4+4 (odds ratio [OR], 3.66; 95% confidence interval [CI], 1.41 to 9.50; P = 0.008) and more advanced tumor stage (stage ≥cT2b versus ≤cT2a; OR, 2.42; 95% CI, 1.14 to 5.10; P = 0.008). 

Among African-American men, 25(OH)D less than 20 ng/mL was associated with increased risk of prostate cancer diagnosis on biopsy (OR, 2.43; 95% CI, 1.20 to 4.94; P = 0.01). Also, among African-American men, 25(OH)D less than 12 ng/mL was associated with Gleason score ≥4+4 (OR, 4.89; 95% CI, 1.59 to 15.07; P = 0.006) and more advanced tumor stage (stage ≥cT2b versus ≤cT2a; OR, 4.22; 95% CI, 1.52 to 11.74; P = 0.003).

"In both European-American and African-American men, severe deficiency was positively associated with higher Gleason grade and tumor stage," the researchers wrote.

In an editorial, William B. Grant, PhD, Sunlight, of the Nutrition, and Health Research Center in San Francisco, CA, noted these findings may be useful in clinical practice.

"Vitamin D level could be added as an additional factor to consider before ordering a biopsy," Grant wrote.

One author disclosed financial ties to the biomedical industry.

References

  1. Murphy AB, Nyame Y, Martin IK, et al. Vitamin D Deficiency Predicts Prostate Biopsy Outcomes. Clin Cancer Res. 2014;doi:10.1158/1078-0432.CCR-13-3085.
  2. Grant WB. Vitamin D Status: Ready for Guiding Prostate Cancer Diagnosis and Treatment? Clin Cancer Res. 2014;doi:10.1158/1078-0432.CCR-14-0369.

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