Rectal Cancer

Rectal Cancer: Adjuvant Chemotherapy May Improve OS After pCR

Rectal Cancer: Adjuvant Chemotherapy May Improve OS After pCR

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After a median follow-up of 3.1 years, patients who received adjuvant chemotherapy had improved rates of survival.

Panitumumab Plus Radiotherapy for Rectal Cancer Fails To Meet Endpoint

Panitumumab Plus Radiotherapy for Rectal Cancer Fails To Meet Endpoint

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Investigators enrolled 98 patients to receive preoperative treatment with intravenous panitumumab plus concurrent radiotherapy.

Rectal Cancer Treatment Regimens

Get the latest treatment options for rectal cancer, including concurrent chemotherapy and radiotherapy and levoleucovorin plus 5-FU.

Rectal Cancer: Complete Radiotherapy Dose Improves Overall Survival

Rectal Cancer: Complete Radiotherapy Dose Improves Overall Survival

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Incomplete neoadjuvant radiotherapy is associated with worse overall survival in patients with locally advanced rectal cancer.

The Rising Trend of Colorectal Cancer in Young Adults

The Rising Trend of Colorectal Cancer in Young Adults

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Compared with adults born in around 1950, those born around 1990 are at a 2-fold higher risk for colon cancers and a 4-fold higher risk for rectal cancers.

Analysis of Radiotherapy Regimens and Timing in Rectal Cancer

Analysis of Radiotherapy Regimens and Timing in Rectal Cancer

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Among patients with rectal cancer, delaying surgery following short-course radiotherapy yields similar outcomes.

Physicians Treating Rectal Cancer More Likely To Choose Short-course Radiotherapy

Physicians Treating Rectal Cancer More Likely To Choose Short-course Radiotherapy

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Radiation oncologists in the US are less likely to offer neoadjuvant short-course radiotherapy over long-course chemoradiotherapy.

Multi-agent Chemotherapy Not Recommended To Replace Chemoradiotherapy in Rectal Cancer

Multi-agent Chemotherapy Not Recommended To Replace Chemoradiotherapy in Rectal Cancer

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Neoadjuvant chemotherapy (NCRT) is superior to neoadjuvant multi-agent chemotherapy (NMAC) for the treatment of stage II or III rectal adenocarcinoma.

Compliance With NCCN Guidelines Benefits Patients With Rectal Cancer

Compliance With NCCN Guidelines Benefits Patients With Rectal Cancer

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Adjuvant chemotherapy is beneficial for patients with locally-advanced, postoperative rectal cancer.

Oxaliplatin With Radiotherapy More Efficacious on Rectal Cancer Than Fluorouracil

Oxaliplatin With Radiotherapy More Efficacious on Rectal Cancer Than Fluorouracil

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Oxaliplatin-based preoperative chemoradiotherapy may yield more pathological complete responses (pCR) for locally-advanced rectal cancer.

Some Patients With Locally Advanced Rectal Cancer May Avoid Surgery

Some Patients With Locally Advanced Rectal Cancer May Avoid Surgery

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Some patients with rectal cancer who experience complete clinical response after neoadjuvant therapy may safely avoid total mesorectal excision.

Left-sided Primary Colorectal Tumor Associated With Longer Survival

Left-sided Primary Colorectal Tumor Associated With Longer Survival

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Metastatic colorectal cancer with the primary tumor located on the left side of the colon is associated with longer survival.

IL17F-rs9463772 Predicts Long-term Outcome in Rectal Cancer

IL17F-rs9463772 Predicts Long-term Outcome in Rectal Cancer

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Single nucleotide polymorphism (SNP) IL17F-rs9463772 represents a prognostic marker of long-term survival in locally advanced rectal cancer.

Pre-treatment Platelet Counts Associated With Prognosis in Stage 2-3 Rectal Cancer

Pre-treatment Platelet Counts Associated With Prognosis in Stage 2-3 Rectal Cancer

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Platelet counts at the time of initial diagnosis had prognostic value for patients with rectal adenocarcinoma receiving neoadjuvant treatment.

5 x 5 Gy, Consolidation Chemotherapy Slightly Superior for cT4 or Fixed cT3 Rectal Cancer

5 x 5 Gy, Consolidation Chemotherapy Slightly Superior for cT4 or Fixed cT3 Rectal Cancer

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Long-course oxaliplatin-based preoperative chemoradiation was similarly efficacious in patients with cT4 or fixed cT3 rectal cancer

Rectal Cancer Surgery Best at 56 Days Post Chemotherapy, Radiation

Rectal Cancer Surgery Best at 56 Days Post Chemotherapy, Radiation

Best length of time to wait to perform surgery for rectal cancer after chemotherapy and radiation treatment.

Wait and Watch After CRT May Be Safe for Patients With Rectal Cancer

Wait and Watch After CRT May Be Safe for Patients With Rectal Cancer

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A substantial proportion of patients with rectal cancer managed by the watch-and-wait approach avoided a major operation.

Capecitabine Established as Standard of Care in Pre-Op Rectal Cancer Setting

Capecitabine Established as Standard of Care in Pre-Op Rectal Cancer Setting

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Capecitabine should be considered a standard of care in the pre-operative rectal cancer setting.

Local Excision After CRT May Be Organ-Preserving Alternative for Rectal Cancer

Local Excision After CRT May Be Organ-Preserving Alternative for Rectal Cancer

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Neoadjuvant chemoradiotherapy followed by local excision may be an organ-preserving alternative in certain patients with clinical T2N0 rectal cancer.

Laparoscopic vs Open Surgery for Rectal Cancer

Laparoscopic vs Open Surgery for Rectal Cancer

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Two studies found that laparoscopic surgery for rectal cancer found that it was potentially inferior to open-surgery.

Adding Aspirin to Preoperative CRT May Be Beneficial for Rectal Cancer

Adding Aspirin to Preoperative CRT May Be Beneficial for Rectal Cancer

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Aspirin might have anticancer activity against rectal cancer during preoperative chemoradiation.

Elderly Patients with Rectal Cancer May Face Similar Survival Outcomes as Younger Patients

Elderly Patients with Rectal Cancer May Face Similar Survival Outcomes as Younger Patients

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Older patients seem to face similar outcomes as younger patients when treated with neoadjuvant chemoradiation for rectal cancer.

Oxaliplatin Added to Standard of Care Therapy Increased Disease-Free Survival for Rectal Cancer

Oxaliplatin Added to Standard of Care Therapy Increased Disease-Free Survival for Rectal Cancer

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Standard combined modality treatment for locally advanced rectal cancer had less disease-free survival than a new CRO/ARO/AIO-04 regimen.

Statin Use Linked with Lower Mortality after Colorectal Cancer Diagnosis

Statin Use Linked with Lower Mortality after Colorectal Cancer Diagnosis

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Cumulative exposure to statins after a diagnosis of colorectal cancer was associated with lower overall mortality.

Possible Link Between rs61764370, Prognosis in Colorectal Cancer

Possible Link Between rs61764370, Prognosis in Colorectal Cancer

Single nucleotide polymorphism in the let-7 complementary site 6 of KRAS mRNA may be a response biomarker in colorectal cancer.

Colorectal Cancer Death "Hotspots" Indicate Need for Increased Screening in Some Areas

Colorectal Cancer Death "Hotspots" Indicate Need for Increased Screening in Some Areas

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Investigators recommend prioritized screening in certain pockets of the U.S. that are statistically identified as colorectal cancer (CRC) death hotspots.

US State Disparities in Colorectal Cancer Rates

US State Disparities in Colorectal Cancer Rates

Greater progress in reducing colorectal cancer incidence, mortality rates observed in Northeastern states compared to Southern states.

Variant rs9929218 Linked with Prognosis of Patients with CRC

Variant rs9929218 Linked with Prognosis of Patients with CRC

Patients with colorectal cancer who have the variant rs9929218 at 16q22 are at an increased risk for worse survival.

High-Dose CRT Plus Watchful Waiting May Be Safe Alternative for Distal Rectal Cancer

High-Dose CRT Plus Watchful Waiting May Be Safe Alternative for Distal Rectal Cancer

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High-dose chemoradiotherapy and watchful waiting might be safe alternative to abdominoperineal resection for treatment of rectal cancer.

mFOLFOX6 Plus Radiotherapy Results in Higher pCR in Rectal Cancer

mFOLFOX6 Plus Radiotherapy Results in Higher pCR in Rectal Cancer

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mFOLFOX6 administered concurrently with radiation therapy resulted in a higher pathological complete response in rectal cancer.

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