Clear-Cell RCC: First Molecular Prognostic Marker for Drug Targeting

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SAN FRANCISCO— A recently discovered molecular prognostic biomarker for clear-cell renal cell cancer has been validated and shown to indicate a four-fold increase in risk of adverse cancer-specific survival and tumor recurrence. Dr. Ari Hakimi MD, from Memorial Sloan-Kettering Cancer Center in New York gave the 2014 ASCO Genitourinary Cancers Symposium his group's findings about the MET oncogene variant which they found to be associated with poor outcomes. He noted that the mechanism made clear by this research could provide a basis for drug targeting in the future while already providing doctors with their first clinically useful molecular biomarker.

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