Diabetes Ups Kidney Cancer Risk in Women

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Women with type 2 diabetes have a 1.5-fold higher risk of renal cell carcinoma compared with non-diabetic women.
Women with type 2 diabetes have a 1.5-fold higher risk of renal cell carcinoma compared with non-diabetic women.

Type 2 diabetes is independently associated with an increased risk of renal cell carcinoma in women, but not men, according to a new study published in Diabetes Care.

In a study of 117,570 women in the Nurses' Health Study (NHS) and 48,866 men in the Health Professionals Follow-up Study (HPFS), Rebecca E. Graff, ScD, of the Harvard T. H. Chan School of Public Health in Boston, and colleagues found that women with type 2 diabetes had a significant 1.5-fold increased risk of RCC compared with non-diabetic women in multivariate analysis. Women with type 2 diabetes for 5 years or less had a significant 2-fold greater risk of RCC compared with non-diabetic women; women with type 2 diabetes for more than 5 years were not at significantly elevated risk of RCC, the investigators reported. 

Among men, type 2 diabetes was not significantly associated with RCC risk.

NHS and HPFS participants were followed up from 1976 and 1986, respectively, through 2014.

The investigators confirmed 418 RCC cases, including 120 fatal cases, during 38 years of follow-up in the NHS, and 302 RCC cases during 28 years of follow-up in the HPFS.

Reference

  1. Graff RE, Sanchez A, Tobias DK, et al. Type 2 diabetes in relation to the risk of renal cell carcinoma among men and women in two large prospective cohort studies. Diabetes Care. 2018; published online ahead of print.

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