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RETROVIR CAPSULES
Viral infections
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Drug Name:

RETROVIR CAPSULES Rx

Generic Name and Formulations:
Zidovudine 100mg.

Company:
ViiV Healthcare

Therapeutic Use:

Indications for RETROVIR CAPSULES:

HIV infection, in combination with other antiretrovirals. Prevention of maternal-fetal HIV transmission.

Adult:

≥18yrs: 600mg daily in divided doses. Renal impairment (CrCl <15mL/min) or on dialysis: 100mg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.

Children:

<6 weeks and/or for vertical transmission: see full labeling. 4 weeks to <18yrs: (4 to <9kg): 24mg/kg/day (12mg/kg twice daily or 8mg/kg 3 times daily); (≥9 to <30kg): 18mg/kg/day (9mg/kg twice daily or 6mg/kg 3 times daily); (≥30kg): 600mg/day (300mg twice daily or 200mg 3 times daily). Alternative dosing based on BSA: 480mg/m2/day (240mg/m2 twice daily or 160mg/m2 3 times daily).

Boxed Warning:

Risk of hematological toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis.

Warnings/Precautions:

Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly and steatosis) occurs. Monitor for hematologic toxicity; reduce dose or suspend if significant anemia and/or granulocytopenia occurs; transfuse if necessary. Risk of myopathy with prolonged use. Renal or hepatic dysfunction: consider reducing dose. Bone marrow suppression. Risk of liver disease. Women, obesity, prolonged nucleoside exposure, or advanced HIV disease: increased risk of toxicity. Monitor for lipoatrophy; if suspected, switch to alternative therapy. Latex allergy (IV). Elderly. Pregnancy. Nursing mothers: not recommended.

See Also:

Zidovudine Tablets

RETROVIR SYRUP

RETROVIR IV

Pharmacological Class:

Nucleoside analogue (reverse transcriptase inhibitor).

Interactions:

Avoid stavudine, doxorubicin, ribavirin, other nucleoside analogues. Caution with other cytotoxic or myelosuppressive drugs (eg, ganciclovir, interferon-alpha, ribavirin). Potentiated by fluconazole, atovaquone, lamivudine, probenecid, valproic acid, methadone. Monitor phenytoin. May be antagonized by clarithromycin, rifampin, ritonavir, nelfinavir. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.

Adverse Reactions:

Headache, malaise, nausea, vomiting, anorexia, insomnia, pain, neuropathy, myositis, thrombocytopenia, anemia, neutropenia, myopathy, lactic acidosis, steatosis, hepatomegaly, immune reconstitution syndrome, pancreatitis, others. Children: also fever, cough.

Generic Availability:

YES

How Supplied:

Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—10


Data provided by MPR.

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