Addition of IFN-a-2b to MAP Does Not Improve Event-Free Survival in Osteosarcoma
the Cancer Therapy Advisor take:
MAP (methotrexate, doxorubicin, and cisplatin) and IFN-a-2b (pegylated interferon alfa-2b) did not improve event-free survival (EFS) when compared to MAP alone among patients with osteosarcoma and good histologic response, according to a study published online ahead of print this week in the Journal of Clinical Oncology.
EURAMOS-1 is an international study where the researchers randomly assigned 716 patients to receive four additional cycles of MAP and IFN-a-2b (n=357) or MAP alone (n=359).
The patients enrolled included ≤ 40 years with resectable high-grade osteosarcoma, good histologic response to induction chemotherapy, more than two cycles of preoperative MAP, complete surgery of primary tumor, less than 10% of viable tumor, and no disease progression.
The primary outcome was EFS, and secondary outcomes were overall survival and toxicity. Three-year EFS for 716 patients was 76% (95% CI: 72, 79) during a median follow-up of 44 months.
The number of EFS events reported was 81 for MAP plus IFN-a-2b and 93 for MAP alone (HR=0.82; 95% CI: 0.61, 1.12; P=0.214). Due to refusal and toxicity from IFN-a-2b, a significant proportion of patients either never started IFN-a-2b or stopped prematurely.
The findings suggest that MAP plus IFN-a-2b was not statistically different from MAP monotherapy for resectable high-grade osteosarcoma with a good histologic response.
MAP and pegylated interferon alfa-2b did not improve event-free survival in patients with osteosarcoma and good histologic response.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- A Vegan Diet and Cancer
- As HPV-Related Cancer Rates Climb, Experts Scrutinize Barriers to HPV Vaccination
- Bowel Preparation for Colorectal Cancer Screening: Improving Outcomes
- Tool for Assessing Frailty Predicts Survival in Newly Diagnosed Multiple Myeloma
- Analysis Supports Flat Dose of Nivolumab 480 mg Every 4 Weeks
- FDA-Approved Breast Cancer Drug Treatments
- A Trained Dog Smells Early-Stage Lung Cancer With a High Degree of Accuracy
- FDA-Approved Prostate Cancer Drug Treatments
- FDA-Approved Colorectal Cancer Drug Treatments
- Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?
- Treatment Delays May Mean Worse Survival in Head and Neck Cancer
- New Combo for Chronic Myeloid Leukemia Shows Activity In Vitro
- Age-adjusted Comorbidity Predicts Survival in Laryngeal Cancer
- Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?
- Role of miR-125a-5p Clarified in Bladder Cancer