Tazemetostat Shows Promise in Epithelioid Sarcoma

Share this content:
Epizyme released the results of its phase 2 study of tazemetostat in epithelioid sarcoma.
Epizyme released the results of its phase 2 study of tazemetostat in epithelioid sarcoma.

Tazemetostat, an orally available, first-in-class EZH2 inhibitor, may become a new treatment option for patients with epithelioid sarcoma, according to interim data from an ongoing phase 2 study presented by Epizyme at the European Society for Medical Oncology (ESMO) 2018 Congress in Munich, Germany.1

Lead study lead investigator, Mrinal Gounder, MD, Memorial Sloan Kettering Cancer Center, New York, New York, said in a press release that as of August 21, 2018, the trial was fully enrolled with 62 patients.1

Initial findings showed tazemetostat produced clinically meaningful activity for patients with epithelioid sarcoma and was generally well tolerated. Twice daily dosing resulted in durable objective responses and encouraging overall survival in both treatment-naive patients and patients who had been previously treated.

Currently, there are few treatment options for patients with this rare and aggressive form of soft tissue sarcoma. Dr Gounder said it is highly encouraging to see these updated efficacy and tolerability data with tazemetostat, suggesting this agent has the potential to be an important treatment option.

The cohort included 24 treatment-naive patients and 38 relapsed and/or refractory patients. Dr Gounder said there have been 6 responders (~25%) in the treatment-naive group and 9 responders (15%) in the overall population. Several patients experienced stable disease and remained on treatment. Only 13% of patients experienced a grade 3 or higher treatment-related adverse event (AE). The most common treatment-related AEs were fatigue (26%), nausea (26%), decreased appetite (16%), vomiting (16%), diarrhea and weight decrease (13%), and anemia (10%).

Reference

  1. Epizyme reports positive data on tazemetostat in epithelioid sarcoma from its phase 2 trial cohort at ESMO [press release]. https://www.businesswire.com/news/home/20181022005063/en/Epizyme-Reports-Positive-Data-Tazemetostat-Epithelioid-Sarcoma. Published October 22, 2018. Accessed November 6, 2018.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs