Sarcoma

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

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More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

High-Dose Busulfan Plus Melphalan Consolidation Therapy May Improve Outcomes in Ewing Sarcoma

High-Dose Busulfan Plus Melphalan Consolidation Therapy May Improve Outcomes in Ewing Sarcoma

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Previous studies have suggested that high-dose therapy with busulfan plus melphalan may confer a benefit to patients with Ewing sarcoma compared with conventional chemotherapy.

Checkpoint Blockade Demonstrates Antitumor Activity in HIV-Associated Kaposi Sarcoma

Checkpoint Blockade Demonstrates Antitumor Activity in HIV-Associated Kaposi Sarcoma

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One patient achieved complete remission in the trial, while 5 other patients experienced partial remission.

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

FDA Guidance: Expansion Cohort Trials Expected to Modernize Oncology Trials

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There is a push to create innovative adaptive trial designs that include more patients and, subsequently, more generalizable data.

Bispecific Antibodies in Cancer

Bispecific Antibodies in Cancer

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Interest in these bioengineered antibodies has been rekindled by the striking success seen in the treatment of some cancers with immunotherapies.

Adoptive Cell Therapy in Solid Tumors Demonstrates Robust Antitumor Effects

Adoptive Cell Therapy in Solid Tumors Demonstrates Robust Antitumor Effects

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Autologous T cells engineered to recognize a dominant immunogenic antigen in incurable metastatic synovial sarcoma produced lasting antitumor responses.

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

Cognitive Functioning Affects the Ability of Patients With Advanced Cancer to Give Informed Consent

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Approximately half of patients with advanced cancer who are enrolled in phase 1 clinical trials do not know the ultimate goal of the study.

Limb-Sparing Surgery Plus Radiotherapy May Improve Survival Outcomes in Soft-Tissue Sarcoma

Limb-Sparing Surgery Plus Radiotherapy May Improve Survival Outcomes in Soft-Tissue Sarcoma

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Limb-sparing surgery plus radiotherapy, now considered the standard of care to treat patients with extremity soft-tissue sarcoma, leads to improved outcomes, confirmed a recent trial.

Chemotherapy May Improve Survival Outcomes in High-Risk Soft-Tissue Sarcoma

Chemotherapy May Improve Survival Outcomes in High-Risk Soft-Tissue Sarcoma

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A study investigating the effects of adjuvant chemotherapy showed that treatment improved metastases-free survival and overall survival among patients with soft-tissue sarcoma and high-risk factors.

Is Genomic Medicine Failing Minority Patients?

Is Genomic Medicine Failing Minority Patients?

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Racial minorities are poorly represented in genomic research databases, raising important questions about whether or not all patients will benefit equally from advances in precision oncology.

Adding Doxorubicin to Standard Chemotherapy May Not Improve Outcomes in Rhabdomyosarcoma

Adding Doxorubicin to Standard Chemotherapy May Not Improve Outcomes in Rhabdomyosarcoma

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Previous studies have demonstrated the efficacy of doxorubicin for the treatment of rhabdomyosarcoma, but its place in combination with established treatment regimens requires further investigation.

<i>ARID1A</i> Mutations Might Predict Tumor Response to Immunotherapy

ARID1A Mutations Might Predict Tumor Response to Immunotherapy

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New findings bolster the case for the predictive utility of ARID1A mutations.

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

Liquid Biopsies and Cancer Detection: New Test Assesses Levels of Circulating Proteins for Early-Stage Diagnosis

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A new test has been shown to be capable of identifying eight different cancers by assessing levels of circulating proteins along with mutations in cell-free DNA.

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

Understanding Telomerase: Higher Quality Images Give Insight Into Developing New Agents for Inhibition

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Telomerase plays a crucial role in tumor proliferation, and a better understanding of its structure will pave the way for new drug development.

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

Efficacy and Hyperemesis Syndrome Associated With Cannabinoid Use in Cancers ― In the Clinic

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Many clinical trials and systematic reviews note that the use of cannabinoids also comes with adverse events, including a clinical entity that has been gaining evidence in the literature over the last decade called cannabinoid hyperemesis syndrome.

Metronomic Maintenance Therapy Significantly Improves Overall Survival in Rhabdomyosarcoma

Metronomic Maintenance Therapy Significantly Improves Overall Survival in Rhabdomyosarcoma

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Researchers sought to determine if maintenance treatment with metronomic chemotherapy would improve survival outcomes in rhabdomyosarcoma.

Can Oncolytic Viruses Improve Immunotherapies?

Can Oncolytic Viruses Improve Immunotherapies?

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Emerging evidence shows that injecting tumors directly into one tumor can trigger systemic antitumor immunity and immune attacks on untreated tumors elsewhere in the body.

Clonally Transmissible Cancers in Nature

Clonally Transmissible Cancers in Nature

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While a recent discovery of a series of communicable cancers has raised concerns, there has been no sign of readily transmittable cancer in people that could spread through a population the way the ones found in other species do.

FDA Grants Orphan Drug Designation to BN-Brachyury for Chordoma

FDA Grants Orphan Drug Designation to BN-Brachyury for Chordoma

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Researchers plan to initiate a phase 2 trial of the vaccine, which will enroll up to 25 patients with metastatic chordoma.

The Hunt for Effective Anticancer Vaccines

The Hunt for Effective Anticancer Vaccines

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Researchers are hotly pursuing 2 distinct biological paths that show remarkable promise in the hunt for an effective anticancer vaccine.

Dasatinib May Be Effective in Imatinib-Resistant Gastrointestinal Stromal Tumors

Dasatinib May Be Effective in Imatinib-Resistant Gastrointestinal Stromal Tumors

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An objective tumor response was reported in 25% of patients.

Uterine Sarcoma Treatment Regimens

Get the latest treatments for uterine sarcoma in this detailed regimen chart, including doxorubicin, gemcitabine, and more.

Soft Tissue Sarcoma Treatment Regimens

View a regimen chart with drug treatment options for soft tissue sarcoma, such as imatinib (Gleevec) and sunitinib (Sutent).

Adjuvant Radiation May Improve Survival in Head and Neck Cancer

Adjuvant Radiation May Improve Survival in Head and Neck Cancer

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The benefit of adjuvant radiotherapy in this setting was previously unestablished.

HIV-Associated Cancers: A Paradigm Shift?

HIV-Associated Cancers: A Paradigm Shift?

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Many HIV-associated cancers develop with the help of oncoviruses — some of which are sexually transmitted.

Anticancer Immunotherapy to Circumvent Tumor Resistance to Immune Checkpoint Inhibitors

Anticancer Immunotherapy to Circumvent Tumor Resistance to Immune Checkpoint Inhibitors

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Most tumors do not respond, or evolve resistance, to immune checkpoint inhibition. Now, researchers at Johns Hopkins have engineered a new class of cancer immunotherapy agents designed to short-circuit key mechanisms of tumors' disruption and evasion of immune system attack.

Phase 1 Trials: Therapy, Not Just Science

Phase 1 Trials: Therapy, Not Just Science

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Phase 1 trials should be considered therapeutic options for some patients.

Immunotherapy and the Risk of Myocarditis

Immunotherapy and the Risk of Myocarditis

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The risk should not discourage patients with cancer from taking these potentially life-extending therapies.

Can A Consortium of Hospitals Help To Reduce Drug Prices?

Can A Consortium of Hospitals Help To Reduce Drug Prices?

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To help curb drug prices, a consortium of hospital groups recently announced plans to form their own nonprofit drug company.

Larotrectinib: Promising for All TRK-Positive Tumors

Larotrectinib: Promising for All TRK-Positive Tumors

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Larotrectinib may have durable antitumor activity in patients with TRK fusion-positive cancers, regardless of tumor type.

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