Research Sheds Light on Cachexia, Further Studies Needed to Implement Treatment Strategies

Share this content:

the Cancer Therapy Advisor take:

Cachexia is a debilitating condition that affects approximately 50% of patients with cancer, raising their risk of death by causing a profound wasting of fat and muscle.

 

According to a mice study published in the advanced online edition of Nature, researchers were able to improve or prevent symptoms of cachexia in mice bearing lung tumors when they administered an antibody that blocked the effects of parathyroid hormone-related protein (PTHrP), a protein secreted by tumor cells. With this knowledge, researchers conducted two experiments with mice that developed lung tumors and cachexia.

 

In the first experiment a polyclonal antibody that neutralizes PTHrP was administered and mice who received the antibody experienced an almost complete prevention of wasting while untreated mice became mildly cachexic. In a second experiment the antibody treatment improved muscle function and prevented the loss of muscle mass while untreated mice developed severe muscle wasting.

 

In all, the findings of these experiments suggest that PTHrP does not directly cause muscle wasting but blocking PTHrP’s activity prevents it. With this in mind, researchers analyzed blood samples from 47 patients with colon cancer who were cachexic and found that PTHrP levels were increased in 17 of those patients.

 

Further research is needed to determine if the PTHrP mechanism is related to only a subset of patients or if it is more likely to be elevated in certain cancers.

  • Cancer Cachexia: A Prognostic Marker
  • The Psychosocial Effects: Patients’ Perspective
  • The Psychosocial Effects: Impact on Caretakers
  • Assessment of Cancer Cachexia
  • Pathophysiology of Cachexia
  • Treatment Options: Progestins
  • Treatment Options: Corticosteroids
  • Nonpharmacological Therapies: Diet and Exercise
SLIDESHOW:

Cancer Cachexia

Cancer Cachexia: No Longer Simply Involuntary Weight Loss
Research Sheds Light on Cachexia, Further Studies Needed to Implement Treatment Strategies
Cachexia is a wasting disorder of adipose and skeletal muscle tissues that leads to profound weight loss and frailty. About half of all cancer patients suffer from cachexia, which impairs quality of life, limits cancer therapy and decreases survival.
READ FULL ARTICLE From Nature

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs