Sonidegib 200 mg May Offer New Treatment Option for Basal Cell Carcinoma

Share this content:

the Cancer Therapy Advisor take:

The benefit-to-risk profile of 200mg sonidegib, a Hedgehog signaling inhibitor, might offer a new treatment option for patients with advanced basal cell carcinoma, a recent study published online first in the journal The Lancet Oncology has shown.

For the ongoing multicenter, double-blind, phase II BOLT trial, researchers enrolled 230 patients with locally advanced basal cell carcinoma who were not amenable to curative surgery or radiation or metastatic basal cell carcinoma. Participants were randomly assigned to either receive sonidegib 200mg or 800mg.

Results showed that during a median follow-up of 13.9 months, 36% (95% CI: 24-50) of those receiving sonidegib 200mg and 34% (95% CI: 25-43) of those receiving sonidegib 800mg achieved an objective response.

In regard to safety, the most common grade 3 to 4 adverse events were elevated creatine kinase and lipase concentration, and serious adverse events occurred in 14% of those the 200mg group and 30% of the 800mg group. 

In addition, fewer adverse events resulting in dose interruption, dose reduction, or treatment discontinuation occurred in the 200mg group.

The indications for cervical cancer screening in asymptomatic average-risk women are described.
The benefit-to-risk profile of 200mg sonidegib might offer a new treatment option for patients with advanced basal cell carcinoma.
Patients with advanced basal cell carcinoma have limited treatment options. Hedgehog pathway signalling is aberrantly activated in around 95% of tumours. We assessed the antitumour activity of sonidegib, a Hedgehog signalling inhibitor, in patients with advanced basal cell carcinoma.

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs