Sonidegib 200 mg May Offer New Treatment Option for Basal Cell Carcinoma
the Cancer Therapy Advisor take:
The benefit-to-risk profile of 200mg sonidegib, a Hedgehog signaling inhibitor, might offer a new treatment option for patients with advanced basal cell carcinoma, a recent study published online first in the journal The Lancet Oncology has shown.
For the ongoing multicenter, double-blind, phase II BOLT trial, researchers enrolled 230 patients with locally advanced basal cell carcinoma who were not amenable to curative surgery or radiation or metastatic basal cell carcinoma. Participants were randomly assigned to either receive sonidegib 200mg or 800mg.
Results showed that during a median follow-up of 13.9 months, 36% (95% CI: 24-50) of those receiving sonidegib 200mg and 34% (95% CI: 25-43) of those receiving sonidegib 800mg achieved an objective response.
In regard to safety, the most common grade 3 to 4 adverse events were elevated creatine kinase and lipase concentration, and serious adverse events occurred in 14% of those the 200mg group and 30% of the 800mg group.
In addition, fewer adverse events resulting in dose interruption, dose reduction, or treatment discontinuation occurred in the 200mg group.
The benefit-to-risk profile of 200mg sonidegib might offer a new treatment option for patients with advanced basal cell carcinoma.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Plastics and Cancer
- Cabozantinib Shows Promising Activity in Osteosarcoma and Ewing Sarcoma
- Real-World Study Shows High Response Rates to T-VEC in Early Metastatic Melanoma
- Using ctDNA to Predict Cancer Recurrence and Guide Therapy Selection
- Are Next-Gen Antibody-Drug Conjugates a Path Forward for Non-Hodgkin Lymphoma and Myeloma?
- First-Line Alectinib Effective in Asian Patients With ALK-Positive Advanced NSCLC
- Pembrolizumab Alone or With Chemotherapy Prolongs OS in Recurrent/Metastatic HNSCC
- Pembrolizumab With Dabrafenib and Trametinib Shows Efficacy, But High TRAEs, in Melanoma
- Assays May Help Researchers Discover Factors Underlying Immunotherapy Response
- Atezolizumab Combo Improved PFS, OS in Stage IV Non-Small Cell Lung Cancer