Trial Seeks to Establish High Dose Vitamin D as Treatment Option for High Risk Melanoma

Share this content:

the Cancer Therapy Advisor take:

The prognosis for patients who have primary cutaneous melanomas that are larger than 4 mm in thickness, are ulcerated and larger than 2 mm in thickness, or are diagnosed with nodal micrometastases is poor and limited treatment options are currently available.

Recently, research has indicated that vitamin D may delay the recurrence of melanoma and improve a patient’s rate of overall survival. Researchers from the Melanoma Institute Australia in North Sydney, Australia, are conducting a pilot placebo-controlled phase II trial that randomly assigns patients into groups to assess the safety, feasibility, and toxicity of on oral loading dose of vitamin D (500,000 IU) followed by a monthly oral dose of vitamin D (50,000 IU) for 2 years.

The study is confined to patients who were treated with a wide excision of the primary for their cutaneous melanoma. Enrollment is open to patients between the ages of 18 and 79 years whose disease is stage IIb, IIc, IIIa (N1a, N2a), or IIIb (N1a, N2a) and have completed primary surgical treatment. Patients will be randomly assigned 2:1 to receive vitamin D treatment or placebo.

The primary endpoints are safety, adherence, and sufficiency of dose. Secondary endpoints of the clinical trial are progression-free survival and participation. If favorable outcomes are measured, this study will become the basis for a multicenter phase III trial.

The Effect of Voriconazole Treatment on Pediatric Patients: A Retrospective Analysis
Prognosis for primary cutaneous melanomas is poor and limited treatment options are currently available.

Patients with primary cutaneous melanomas that are ulcerated and >2 mm in thickness, >4 mm in thickness and those with nodal micrometastases at diagnosis, have few options for adjuvant treatment.

Recent studies have suggested a role for vitamin D to delay melanoma recurrence and improve overall prognosis.

READ FULL ARTICLE From Mdlinx

Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters



Regimen and Drug Listings

GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION

Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs