At Year 3, Survival Curve of Ipilimumab-Treated Advanced Melanoma Begins to Plateau
the Cancer Therapy Advisor take:
According to a pooled analysis published in the Journal of Clinical Oncology, researchers have found that there is a plateau in the survival curve at 3 years for patients with unresectable or metastatic melanoma treated with ipilimumab.
In order to determine a more precise estimate of long-term survival observed for those with advanced melanoma treated with ipilimumab, researchers performed a pooled analysis of overall survival using data from various phase 2 and 3 studies.
The researchers analyzed overall survival data for 1,861 patients from 12 studies of ipilimumab. Results showed a median overall survival of 11.4 months (95% CI: 10.7 - 12.1 months). Of those, 254 patients had at least 3 years of survival follow-up.
The researchers found that the survival curve began to level off at year 3. For all patients, the 3-year survival rate was 22% versus 26% for treatment-naive patients and 20% for previously treated patients.
When researchers included an additional 2,985 patients from an expanded access program, the median overall survival was 9.5 months (95% CI: 9.0 - 10.0 months). In that analysis, a plateau at 21% in the survival curve occurred beginning around year 3.
The authors note that the findings add to the evidence supporting the durability of long-term survival in patients with advanced melanoma treated with ipilimumab.
There is a plateau in the survival curve at 3 years for patients with unresectable or metastatic melanoma treated with ipilimumab.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Breast Implant-Associated Anaplastic Large Cell Lymphoma — In the Clinic
- Immune Checkpoint Inhibitors for NSCLC: Current and Future Approaches
- Can A Consortium of Hospitals Help To Reduce Drug Prices?
- Clostridium Difficile Infection in Patients With Cancer — In the Clinic
- 5α-Reductase Inhibitors Do Not Increase Risk of High-Grade Prostate Cancer
- FDA Approves Front-Line Brentuximab Vedotin Plus Chemotherapy for Hodgkin Lymphoma
- NSCLC: Pretreatment Weight Loss May Be Linked to Socioeconomic Status
- Targeted and Immunotherapies for Metastatic Renal Cell Carcinoma
- Atezolizumab, Carboplatin, Nab-Paclitaxel Combination Prolongs PFS in NSCLC
- Model May Identify Patients With Gastric Cancer Likely To Benefit From Chemotherapy