Vitiligo-Like Depigmentation During Immunotherapy Associated with Improved Survival
the Cancer Therapy Advisor take:
According to a new study published in the Journal of Clinical Oncology, researchers in the Netherlands have found that although vitiligo-like depigmentation occurs only in a small number of patients with melanoma treated with immunotherapy, there is an evident survival benefit in these patients.
Vitiligo-like depigmentation in patients with melanoma was thought to be associated with more favorable clinical outcomes. Therefore, researchers sought to determine the cumulative incidence of vitiligo-like depigmentation and the prognostic value of vitiligo development on survival in patients with stage III to IV melanoma treated with immunotherapy.
Researchers identified 139 studies that included 139 treatment arms. Of those, 11 studied general immune stimulation, 84 studied vaccines, 28 were antibody-based, and 16 studied adoptive cell transfer. The studies included a total of 5,737 patients. Results showed the overall cumulative incidence of vitiligo was 3.4% (95% CI: 2.5 - 4.5%).
Researchers also found that vitiligo development was associated with progression-free survival (HR = 0.51; 95% CI: 0.32 - 0.82; P < 0.005) and overall survival (HR = 0.25; 95% CI: 0.10 - 0.61; P < 0.003).
The findings suggest that patients who developed vitiligo had two to four times less risk of disease progression and death compared with those who did not develop vitiligo.
Although vitiligo-like depigmentation occurs only in patients with melanoma treated with immunotherapy, there is an evident survival benefit.
Sign Up for Free e-newsletters
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|
|Renal Cell Carcinoma||Regimens||Drugs|
Cancer Therapy Advisor Articles
- Immune Checkpoint Inhibitors for NSCLC: Current and Future Approaches
- Can A Consortium of Hospitals Help To Reduce Drug Prices?
- Clostridium Difficile Infection in Patients With Cancer — In the Clinic
- Erdafitinib Granted FDA Breakthrough Therapy Designation for Urothelial Carcinoma
- NSCLC: Stratifying Patients With Complex EGFR Mutations
- Nivolumab Plus Ipilimumab Improves Overall Survival, ORR in Renal Cell Carcinoma
- Encorafenib, Binimetinib May Be Effective in BRAF-Mutant Melanoma
- CLL: Venetoclax Plus Rituximab Improves 2-Year PFS
- Confronting Racial Disparities in Prostate Cancer Survival Outcomes
- FDA Approves Front-Line Brentuximab Vedotin Plus Chemotherapy for Hodgkin Lymphoma