Skin Cancer Risk Increased by HPV Infection

Share this content:
(ChemotherapyAdvisor) – Infection with specific subtypes of human papillomavirus (HPV) is a risk factor for squamous cell carcinoma (SCC) of the skin, according to an international team of researchers. This conclusion is based on study entitled “Case–Control Study of Cutaneous Human Papillomaviruses in Squamous Cell Carcinoma of the Skin,” which was published in the August issue of Cancer Epidemiology, Biomarkers & Prevention.

In this study, the investigators aimed to determine whether cutaneous HPV infection is a risk factor for SCC of the skin. To meet their aim, the investigators conducted a case-control study (n=173 SCC cases; n=300 SCC-negative controls). For each patient, seropositivity against one or more cutaneous HPV types was measured: alpha, beta, gamma, mu, and nu. Additionally, patient SCC tumors (n=159) were tested for the presence of HPV-beta DNA.

The investigators found a positive association between SCC and seropositivity to HPV-beta (OR, 1.93; 95% CI, 1.23–3.02). Additionally, SCC was associated with HPV 8 (OR, 1.80; 95% CI, 1.14–2.84), HPV 17 (OR, 1.59; 95% CI, 1.02–2.49), and HPV 10 (OR, 2.24; 95% CI, 1.04–4.85).

“When DNA-positive SCC cases were compared with controls, strong serologic associations were observed for HPVs 5 (OR, 3.48; 95% CI, 1.27–9.59), 17 (OR, 3.36; 95% CI, 1.29–8.72), and 24 (OR, 3.79; 95% CI, 1.24–11.5),” the investigators reported.

The investigators concluded that HPV-beta infections are associated with SCC, a finding that that “may lead to improved characterization of high-risk individuals and the development of novel prevention strategies.”


Related Resources

You must be a registered member of Cancer Therapy Advisor to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Prostate Cancer Regimens Drugs
Rare Cancers Regimens
Renal Cell Carcinoma Regimens Drugs
Skin Cancer Regimens Drugs
Urologic Cancers Regimens Drugs