Skin Cancer Risk Increased by HPV Infection
In this study, the investigators aimed to determine whether cutaneous HPV infection is a risk factor for SCC of the skin. To meet their aim, the investigators conducted a case-control study (n=173 SCC cases; n=300 SCC-negative controls). For each patient, seropositivity against one or more cutaneous HPV types was measured: alpha, beta, gamma, mu, and nu. Additionally, patient SCC tumors (n=159) were tested for the presence of HPV-beta DNA.
The investigators found a positive association between SCC and seropositivity to HPV-beta (OR, 1.93; 95% CI, 1.23–3.02). Additionally, SCC was associated with HPV 8 (OR, 1.80; 95% CI, 1.14–2.84), HPV 17 (OR, 1.59; 95% CI, 1.02–2.49), and HPV 10 (OR, 2.24; 95% CI, 1.04–4.85).
“When DNA-positive SCC cases were compared with controls, strong serologic associations were observed for HPVs 5 (OR, 3.48; 95% CI, 1.27–9.59), 17 (OR, 3.36; 95% CI, 1.29–8.72), and 24 (OR, 3.79; 95% CI, 1.24–11.5),” the investigators reported.
The investigators concluded that HPV-beta infections are associated with SCC, a finding that that “may lead to improved characterization of high-risk individuals and the development of novel prevention strategies.”