Infection Risk Higher in Cancer Patients With Central Venous Cather Use

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Infection Risk Higher in Cancer Patients With Central Venous Cather Use
Infection Risk Higher in Cancer Patients With Central Venous Cather Use

(HealthDay News) -- Long-term central venous catheters (CVCs) are associated with an increased risk of infection in older adults with cancer, according to research published online in the Journal of Clinical Oncology.

Allison Lipitz-Snyderman, PhD, of the Memorial Sloan Kettering Cancer Center in New York City, and colleagues analyzed data from 2005 to 2007 for patients diagnosed with invasive or noninvasive breast cancer; invasive colorectal, head and neck, lung, or pancreatic cancer; or non-Hodgkin lymphoma.

All patients were older than 65 years. The authors sought to assess the effect of long-term CVC use on infection risk.

The researchers found that CVC use was associated with significantly increased risk of infection among older patients with cancer.

During CVC exposure, increased risk of infection was observed among patients with breast cancer (adjusted hazard ratio [aHR], 6.19; 95% confidence interval [CI], 5.42 to 7.07) or pancreatic cancer (aHR, 2.93; 95% CI, 2.58 to 3.33).

The same associations were found after adjusting for propensity to receive a CVC and limiting the cohort to only include individuals at high risk of infections.

"Careful assessment of the need for long-term CVCs and targeted strategies for reducing infections are critical to improving cancer care quality," the researchers wrote.


  1. Lipitz-Snyderman A, Sepkowitz KA, Elkin EB, et al. Long-Term Central Venous Catheter Use and Risk of Infection in Older Adults With Cancer. J Clin Oncol. 2014;doi:10.1200/JCO.2013.53.3018.

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