An Investigation of the Plasma Metabolome in Patients With Small Cell Lung Cancer
Exposure of patients with small cell lung cancer to platinum-based chemotherapy resulted in altered levels of specific plasma lipids.
Diagnosis & Disease Information
Limited Clinical Benefit for the Combination of TRC102 and Temozolomide in Refractory Colorectal Cancer
The median number of prior treatments for patients with relapsed colorectal cancer enrolled in this phase 2 study was 6.
Tumor Biopsy Found Less Effective Than Liquid Biopsy for Identifying Resistance Mechanisms in Some GI Cancers
In 78% of patients, circulating cell-free tumor DNA identified a possible mechanism of acquired resistance not identified by standard tumor DNA sequencing.
The Predictive Ability of a Cancer Subtype Ontology Assignment
The Cancer Subtype Ontology resource includes 840 different cancer subtypes, many of which are novel.
Investigating CD133 as a Biomarker of Prostate Cancer Disparity in African American Men
CD133 has often been used as a marker of cancer stem cells.
COLOMATE: Using a Liquid Biopsy in CRC to Select a Molecularly Targeted Therapy
The companion study arms under the COLOMATE trial umbrella will include those that specifically enroll patients with HER2-amplified or EGFR-mutant disease.
Two RNA Sequencing Inflammatory Scores as Predictors of Benefit From Pembrolizumab in Advanced Breast Cancer
The search for robust biomarkers in the tumor immune microenvironment that could be predictive of response to immune checkpoint blockade is ongoing.
FFPE Tissue Specimens Deemed Adequate for Molecular Studies: NCI-SEER
Regions of tumor and normal tissue on FFPE tissue specimens obtained from the NCI SEER-linked Virtual Tissue Repository were annotated by a pathologist.
Novel Toxicities, Anticancer Activity of Anti-CD22 CAR-T Therapies Revealed
Hemophagocytic lymphohistiocytosis is a rare, but potentially fatal, complication of immunotherapy, resulting from immune hyperactivation.
Colorectal Cancer Pathogenesis May Be Driven by Alterations in MACROD2
The appearance of structural variants in MACROD2, culled from sequencing data from patients with colorectal cancer, may be a hallmark of CRC pathogenesis.
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