Single Nucleotide Polymorphisms Associated With ALL in Children With Down Syndrome
Researchers conducted a meta-analysis to evaluate possible associations between certain genetic variants and risk for acute lymphoblastic leukemia.
Acute Lymphoblastic Leukemia
No Link Between Nutritional Deficiencies, Vincristine-Induced Neuropathy in Pediatric Acute Lymphoblastic Leukemia
Of patients who experienced vincristine-induced neuropathy, approximately half were identified as having undernutrition.
Incidence of Late Events After CAR-T Therapy for Relapsed/Refractory B-Cell Malignancies
Infections occurred in 33 of 54 patients for whom data were available, and 80% of infections were treated in an outpatient setting.
Second-Generation CD19 CAR-T Therapy Shows Activity in B-ALL
A second-generation CD19 chimeric antigen receptor T cell therapy appeared to be effective in patients with B-cell acute lymphoblastic leukemia.
Treatment Delays With CAR-T Therapy: A High Price to Pay
A treatment delay of 6 months was found to result in up to a 67.3% loss in social value for patients receiving chimeric antigen receptor T-cell therapy.
Anti-CD19 CAR-T Therapy Shows Early Efficacy in ALL
ZUMA-3 results show revised adverse event management strategy mitigated treatment-related events.
Flow Cytometry as a Relapse Risk Assessment Tool in T-Cell Acute Lymphoblastic Leukemia
An alternative measure of relapse risk is needed in patients for whom no polymerase chain reaction marker is available.
Number of Comorbidities Linked to Risk of Thromboembolism in Leukemia, Lymphoma
A retrospective study sought to determine the risk factors for thromboembolism in patients with acute leukemia or lymphoma.
Greater Infection Risk With Unrelated Transplant Donors in Pediatric Acute Lymphoblastic Leukemia
The increased risk for infection seen in pediatric patients receiving transplants from unrelated donors could be a result of intensified graft-versus-host disease prophylaxis.
Less-Frequently Dosed Pegylated Asparaginase: Found as Safe and Effective as Standard Pegaspargase in Younger Patients With ALL
Postinduction, median nadir serum asparaginase activity was similar in patients receiving either drug, suggesting a need for dosing optimization.
Next post in ASCO 2019
