Induction Therapy and Hematopoietic Stem Cell Transplantation for Mixed-Phenotype Acute Leukemia
Among patients treated with an acute lymphoblastic leukemia induction regimen, 72% achieved end-of-induction complete remission.
Acute Lymphoblastic Leukemia
Corticosteroid-Induced Psychiatric Disorders Are Common in Young Patients With Acute Lymphoblastic Leukemia, Lymphoma
This study addressed the dearth of information on the incidence of psychiatric disorders related to corticosteroid-containing treatment in patients with hematologic malignancies.
Exercise Intolerance, Neurocognitive Dysfunction in Survivors of Childhood Acute Lymphoblastic Leukemia
Exercise tolerance was found to be associated with verbal fluency, dominant motor speed, and math academics, among other neurocognitive metrics.
Reduced Rates of Central Nervous System Relapse in Patients With High-Risk Pediatric ALL
Central nervous system relapse rates in pediatric acute lymphoblastic leukemia can be reduced with additional early doses of intrathecal chemotherapy.
Treosulfan May Offer a New Standard for Prehematopoietic Stem Cell Transplantation Conditioning
Patients receiving treosulfan and fludarabine experienced improved event-free and overall survival compared with patients receiving busulfan and fludarabine.
19-28z CAR-T Therapy in Children and Young Adults With Relapsed/Refractory ALL: Promising Early Results
The response rate to 19-28z CAR-T therapy was 100% for those with pretreatment MRD who received preconditioning chemotherapy with high-dose cyclophosphamide.
Measurable Residual Disease Status: A Strong Prognostic Indicator in B-Cell Acute Lymphoblastic Leukemia
Researchers conducted a meta-analysis of 23 studies to determine the influence of measurable residual disease on survival outcomes.
Young Patients Report Improved Quality of Life After Tisagenlecleucel for B-Cell Acute Lymphoblastic Leukemia
Using EQ-5D and PedsQL, researchers determined the long-term effect of tisagenlecleucel treatment on quality of life for pediatric and young patients with R/R B-cell ALL.
Single Nucleotide Polymorphisms Associated With ALL in Children With Down Syndrome
Researchers conducted a meta-analysis to evaluate possible associations between certain genetic variants and risk for acute lymphoblastic leukemia.
No Link Between Nutritional Deficiencies, Vincristine-Induced Neuropathy in Pediatric Acute Lymphoblastic Leukemia
Of patients who experienced vincristine-induced neuropathy, approximately half were identified as having undernutrition.
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