Anti-CD19 CAR-T Therapy Shows Early Efficacy in ALL
ZUMA-3 results show revised adverse event management strategy mitigated treatment-related events.
Acute Lymphoblastic Leukemia
Flow Cytometry as a Relapse Risk Assessment Tool in T-Cell Acute Lymphoblastic Leukemia
An alternative measure of relapse risk is needed in patients for whom no polymerase chain reaction marker is available.
Number of Comorbidities Linked to Risk of Thromboembolism in Leukemia, Lymphoma
A retrospective study sought to determine the risk factors for thromboembolism in patients with acute leukemia or lymphoma.
Greater Infection Risk With Unrelated Transplant Donors in Pediatric Acute Lymphoblastic Leukemia
The increased risk for infection seen in pediatric patients receiving transplants from unrelated donors could be a result of intensified graft-versus-host disease prophylaxis.
Less-Frequently Dosed Pegylated Asparaginase: Found as Safe and Effective as Standard Pegaspargase in Younger Patients With ALL
Postinduction, median nadir serum asparaginase activity was similar in patients receiving either drug, suggesting a need for dosing optimization.
Patterns in Late Morbidity Burden Changed for Survivors of Pediatric ALL
A retrospective cohort study from St Jude Children’s Research Hospital sought to determine how long-term effects of treatment have evolved for survivors of pediatric ALL.
Resistance to CAR-T in B-Cell ALL Discussed at ASGCT Meeting
New possible mechanisms of resistance to CD19 CAR-T were put forth for B-cell acute lymphoblastic leukemia.
Standardization of Minimal Residual Disease Measurements in Philadelphia-Positive ALL
Variability in minimal residual disease measurement techniques inhibits the ability to compare data across laboratories and clinical trials.
Improved Long-Term Outcomes After Stronger Postinduction Intensification for Acute Lymphoblastic Leukemia
Patients with rapid early response demonstrated increased event-free and overall survival when receiving augmented postinduction intensification regimens.
Severe Neurotoxicity Following CAR-T Cell Therapy Associated With Poor Prognosis
CAR-T–related neurotoxicity was found to be associated with the presence of cytokine release syndrome.
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