Data Mining to Develop Mutation-Specific Treatments in Acute Myeloid Leukemia
Integrating mutation-specific data across repositories and portals may lead to novel therapeutically actionable insights for acute myeloid leukemia.
Acute Myeloid Leukemia
Cytogenetic Abnormalities Provide Prognostic Value in Predicting Acute Myeloid Leukemia Outcomes
Patients with a monosomal or complex karyotype were found to have lower rates of leukemia-free survival compared with patients with a normal karyotype.
Antibiotic Discontinuation in Neutropenic Patients With Acute Myeloid Leukemia
Discontinuing antibacterial therapy in neutropenic patients with acute myeloid leukemia did not lead to excessive mortality or severe infections.
Risk of Rare Blood Cancers Rises After Solid Tumor Chemotherapy
For 22 of 23 solid cancers investigated in a new study, the risk of therapy-related myelodysplastic syndrome or acute myeloid leukemia increases after chemotherapy.
Positive Phase 2 SY-1425 Results for AML and MDS
Nancy Simonian, MD, discusses the results at ASH 2018.
Clinical Activity in Patients With MCL-1-Dependent R/R AML
Joshua Zeidner, MD, discusses stage 1 findings at the ASH 2018 meeting.
Updated Findings on Treatment Options for Patients With AML
Rod A. Humerickhouse, MD, PhD, discusses findings from AbbVie at the ASH 2018 meeting.
No Survival Benefit Found With Allogeneic Hematopoietic Cell Transplantation in Older Patients With AML
At first glance, the data on 695 patients with advanced myeloid leukemia (AML) seem to support a survival advantage of allogeneic hematopoietic cell transplantation (HCT) compared with no transplantation.
Posttransplant AML Relapse Linked to Pathways Influencing Immune Function
There were no previously unknown AML-specific mutations or structural variations in immune-related genes among patients with AML who had undergone transplant.
Enhancing the Delivery of Checkpoint Inhibitors in Patients with AML
In mice models, the systemic delivery of blood platelets that were coated with anti-PD-1 antibodies and conjugated to HSCs halted the recurrence of leukemia.
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