Clofarabine, Cytarabine Combo Significantly Prolongs Survival in AML Patients
Clofarabine plus cytarabine (Clo+Ara-C) significantly prolongs event-free survival (EFS).
Clofarabine plus cytarabine (Clo+Ara-C) significantly prolongs event-free survival (EFS).
Survivin is a prognostic biomarker in acute myeloid leukemia (AML) and remains a potentially important target for leukemia therapy.
Myeloid neoplasms that develop following radiation therapy differ from those arising from chemotherapy.
(ChemotherapyAdvisor) – One of the largest randomized phase 3 trials to date in patients ≥65 years of age with newly diagnosed acute myeloid leukemia (AML) has found that decitabine improved response rates compared with low-dose cytarabine or supportive care and had a possible survival advantage, according to results published in the Journal of Clinical Oncology…
A new mutation in human acute myeloid leukemia (AML) represents a valid therapeutic target.
Investigators suggest the daunorubicin/cytarabine/cladribine regimen be considered the new standard of care as remission induction.
Fractionated lower doses of gemtuzumab ozogamicin allows safe delivery of higher cumulative doses and substantially improves outcomes in adults with de novo acute myeloid leukemia (AML).
Phase 1/2 study shows positive responses for plerixafor combined with chemotherapy for AML.
A study of patients with acute myeloid leukemia (AML) has identified TET2 mutations in 7.6% that did not affect response to therapy or survival.
Relapse of acute myeloid leukemia (AML) is associated with acquisition of new mutations and clonal evolution.