ctDNA Monitoring Shows Promise for Anal Cancer Patients Receiving Chemoradiation
Monitoring of ctDNA may be useful for early response assessment in patients with anal cancer receiving chemoradiation, a study suggests.
Diagnosis & Disease Information
Treating Anal HSIL Cuts Anal Cancer Risk in Persons With HIV
The rate of progression to anal cancer was lower for patients receiving treatment for anal high-grade squamous intraepithelial lesions.
Pembrolizumab Yields ‘Encouraging’ Survival Outcomes in Advanced Anal Cancer
The median progression-free survival was 2.0 months, and the median overall survival was 11.9 months.
Preclinical Work on Red Blood Cell-Based Therapies in HPV-Positive Solid Tumors Provides Rationale for Clinical Trials in Humans
A microfluidics platform for engineering activated antigen carrier immunotherapies from red blood cells showed promising preliminary results in a mouse model.
Phase 2 Results: Pembrolizumab Shows Antitumor Activity and a Manageable Safety Profile in Anal Squamous Cell Carcinoma
This single-arm, phase 2 study of pembrolizumab in advanced solid tumor cancers did not limit patient enrollment based on tumor PD-L1 expression level.
Incidence of Squamous Cell Carcinoma of the Anus Increasing
Greater increase seen for distant-stage and regional-stage SCCA than for localized-stage SSCA.
Rates of Anal Cancer Precursors High in Women Living With HIV
Authors call for new screening strategies for anal cancer prevention in women living with HIV.
High IDO1 Tumor Expression May Predict Poor Overall Survival in Patients With Anal Cancer
High tumor expression of IDO1 may identify whether a patient is likely to respond to immunotherapy, according to study authors.
Standard Therapy for Anal Cancer May Not Affect Long-term Outcomes Among HIV Patients
Healthy HIV-positive patients with anal cancer are treated with standard chemoradiotherapy, but whether this patient population experiences worse outcomes or more severe toxic effects was previously unknown.
Phase 1b/2 Study of DPX-E7 + Cyclophosphamide in HPV-positive Cancers
Researchers are evaluating whether DPX-E7 vaccination is safe and will improve outcomes among patients with HPV-positive head and neck, cervical, or anal cancer.
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