Nivolumab Active in Squamous Cell Carcinoma of the Anal Canal
Nivolumab was clinically active and well-tolerated among patients with treatment-refractory metastatic squamous cell carcinoma of the anal canal (SCCA).
Diagnosis & Disease Information
Adding Cetuximab to HIV-associated SCCAC Therapy May Reduce LRF
Addition of cetuximab to definitive chemoradiation (CRT) reduces locoregional failure rates but is associated with grade 4 toxicity.
Higher Facility Volume Linked to Improved OS Among Patients With Anal Cancer
Care at radiation oncology centers with a higher volume is associated with improved survival among patients with squamous cell carcinoma of the anal canal.
Patterns in PI3K Signaling Pathway Aberrations Evaluated
Researchers argue that combination therapies targeting both mutations in the PI3K pathway and HER2 or hormone receptor overexpression should be evaluated across cancer types.
Incidence Rates for Anal Carcinoma, Adenocarcinoma Have Increased Significantly
Incidence rates (IRs) of anal squamous cell carcinoma (SCC) and squamous carcinoma in situ (CIS) have significantly increased overtime.
HPV Type 16 Seropositivity Common Before Anal Cancer
Human papillomavirus (HPV) type 16 (HPV16) seropositivity is relatively common before anal cancer diagnosis.
Gardasil 9 HPV Vaccine Approved
The FDA has approved Gardasil 9 (9-valent human papillomavirus types) vaccine for the prevention of cervical, vulvar, vaginal, anal cancers.
For HPV-Associated Anal Cancer, ADXS-HPV Immunotherapy May Be Effective
Results of ADXS-HPV with standard chemo and radiotherapy for HPV-associated anal cancer who have a high risk of recurrence.
Human Papilloma Virus and Squamous Cell Carcinoma of the Anus
[Clin Med Insights Oncol] HPV is a risk factor for anal intraepithelial neoplasia (AIN). Etiology, anatomy, pathogenesis, management of squamous cell carcinoma (SCC) discussed.
HPV Screening Linked to Increased U.S. Cases of Anal Canal Carcinoma
Increased screening and changing demographics may explain the sharp rise in cases of squamous cell carcinoma of the anal canal and anal carcinoma in situ.
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