High Neutrophil-Lymphocyte Ratio Linked to Worse Survival in Head and Neck Cancer
A high neutrophil-lymphocyte ratio appears to be an independent predictor of outcomes for some patients with head and neck cancer.
Diagnosis & Disease Information
Gene Mutations and Transcriptional Signatures Correlate With Response to Therapy in Advanced Renal Cell Carcinoma
A comprehensive analysis of advanced kidney cancer tumors from the IMmotion151 trial provided new insights on the tumor features that underpin responses to therapy.
ctDNA Level Is a Potential Prognostic Biomarker for Immunotherapy
The ctDNA level at baseline was associated with response, PFS, and OS with pembrolizumab in patients with different tumor types.
One-Third of Glioblastomas Had Molecular Changes at Recurrence
Repeat biopsies may be needed prior to patient inclusion in targeted-therapy trials.
RBC Count, Erythrocyte Sedimentation Rate May Be Useful Biomarkers of Polycythemia Vera
Although some red blood cell-related parameters used in the diagnosis of PV may be misleading in the setting of iron-deficiency, RBC count may be an effective biomarker for PV when combined with ESR.
Patient Simulation Project in Lung, Breast Cancers Points to Improvements in Quality of Care
Palliative care and end-of-life needs were not addressed for approximately 40% of simulated patients who would have been eligible for this approach.
Soluble PD-1 Is a Potential Biomarker in Metastatic Melanoma in Patients Treated With Autologous Vaccines
A small study on patients with metastatic melanoma who were treated with autologous vaccines in a phase 2 clinical trial suggests that soluble PD-1 may have potential as a prognostic biomarker.
Some Targeted Therapies May Miss the Mark
Ten different drugs continued to kill cancer cells even when their target proteins were removed.
IHC Assays for PD-L1 Lack Concordance in Metastatic TNBC
An exploratory analysis showed that the VENTANA PD-L1 SP142 IHC assay had subpar concordance with 2 other PD-L1 IHC assays that are not approved for metastatic TNBC.
Serum-Free Light Chain Multiple Myeloma
A sudden increase of serum-free light chains was associated with treatment-induced tumor lysis syndrome in multiple myeloma, suggesting a possible risk factor.
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