The Predictive Ability of a Cancer Subtype Ontology Assignment
The Cancer Subtype Ontology resource includes 840 different cancer subtypes, many of which are novel.
Diagnosis & Disease Information
COLOMATE: Using a Liquid Biopsy in CRC to Select a Molecularly Targeted Therapy
The companion study arms under the COLOMATE trial umbrella will include those that specifically enroll patients with HER2-amplified or EGFR-mutant disease.
FFPE Tissue Specimens Deemed Adequate for Molecular Studies: NCI-SEER
Regions of tumor and normal tissue on FFPE tissue specimens obtained from the NCI SEER-linked Virtual Tissue Repository were annotated by a pathologist.
Novel Toxicities, Anticancer Activity of Anti-CD22 CAR-T Therapies Revealed
Hemophagocytic lymphohistiocytosis is a rare, but potentially fatal, complication of immunotherapy, resulting from immune hyperactivation.
NCI-MATCH: No Objective Responses to Palbociclib in Patients With CCND-Amplified Tumors
In the palbociclib/CCND-amplification arm of the NCI MATCH trial, 42% of patients had received more than 4 prior lines of therapy.
High Baseline Inflammatory Biomarker Levels Linked to Shorter OS in mTNBC
On multivariate analyses, high baseline levels of IL-6 and CRP, but not IL-8, were associated with shorter OS in patients with breast cancer receiving atezolizumab.
Immune Biomarkers as Predictors of Response to Checkpoint Blockade in Breast Cancer
Results from this study showed that a close spatial distribution between CD3-positive T cells and cancer cells was a biomarker for response to pembrolizumab.
Study Finds Shortage of Medical Geneticists
How will oncology deal with a lack of medical genetics professionals to help treat cancer with precision genomic medicine?
Contrast-Enhanced MRI Characterization of Brain Cancers
According to researchers, neovascularization is more common in glioblastoma, and extravasation is more common in primary CNS lymphoma.
Genomic Characterization of Chemoresistant Metastatic Small Cell Lung Cancer
Whole-genome sequencing of tumor specimens from patients with chemoresistant SCLC showed evidence of the deletion of multiple tumor suppressor genes.
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