Racial Differences in Immune Escape Mechanisms of Ovarian Cancer
High expression of indoleamine 2.3-dioxygenase pathway genes correlated with the presence of immune escape mechanisms in ovarian cancers, according to researchers.
Diagnosis & Disease Information
Simultaneous Sequencing of Paired Germline and Somatic Specimens Enhanced Clinical Care in Ovarian Cancer
Simultaneous molecular characterization of paired germline and tumor specimens may gain importance as more targeted therapies become available.
High Monocyte-to-Lymphocyte Ratio Predictive of OS in Advanced Gallbladder Cancer
A high monocyte-to-lymphocyte ratio and a high platelet-to-lymphocyte ratio were predictive of poor OS in patients with advanced gallbladder cancer treated with chemotherapy.
Deep Analysis of BCR-ABL Transcripts Predicts Tyrosine Kinase Inhibitor Response in CML
Although patients with CML may not be eligible for TKI discontinuation based on transcript alone, the type of transcript seen may have some implications for loss of treatment remission.
clonoSEQ and MRD Testing in Multiple Myeloma and ALL
Medicare coverage has been announced for Adaptive Biotechnologies’ clonoSEQ® next-generation sequencing assay for the detection of minimal residual disease (MRD) after treatment for multiple myeloma or B-cell acute lymphoblastic leukemia (ALL) — a key step toward its use for patient care in cancer clinics in the United States.1,2The FDA announced regulatory approval for the assay…
Clinical Applications of Liquid Biopsies in Cancer
This fact sheet describes liquid biopsies and their uses in oncology.
Ibrutinib Plus Nivolumab in 4 Cohorts of Patients With R/R NHL or CLL
According to results of an exploratory study, patients with Richter transformation may benefit from treatment with ibrutinib plus nivolumab.
PCa Genomic Test May Predict Outcomes More Accurately in African-American Men
The Decipher genomic classifier predicted metastases and prostate cancer-specific mortality following radical prostatectomy with greater precision in African-American men.
Immune Signature for Renal Cell Papillary Carcinoma Predicts Outcome
Researchers identified 15 genes that they said independently predict the survival outcome of patients with kidney renal papillary cell carcinoma.
A 5-Feature Radiomics Model to Predict Refractory Disease in Early-Stage Hodgkin Lymphoma
A study of the use of precision medicine-based “radiomic” features to evaluate risk of refractory disease in early-stage Hodgkin lymphoma showed promising results.
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