Efficacy for Thalidomide, Irinotecan Combo Inadequate for Glioma
Combination chemotherapy including thalidomide and irinotecan is not adequately effective for the treatment of aplastic glioma.
Diagnosis & Disease Information
Variant of Glioma Susceptibility Found
A new genetic variant in the TP53 gene predicts susceptibility to the development of gliomas and may shed light on its etiology.
Perifosine Prolongs Survival in Neuroblastoma Patients
Perifosine shows activity against chemoresistant and radioresistant neuroblastoma.
Childhood CT Scans May Triple Risk of Leukemia, Brain Tumors, But Absolute Risk is Low
Children <15 years of age exposed to radiation from two to three CT scans to the head may have triple the risk of developing brain cancer, while five to ten scans can triple the risk of developing leukemia.
Chemotherapy + Radiotherapy Ups Survival in Anaplastic Oligodendroglioma
Patients with anaplastic oligodendroglioma with co-deletion for chromosomes 1p and 19q survive significantly longer after receiving chemotherapy immediately prior to radiotherapy, according to long-term follow-up of a randomized phase 3 study presented at the 2012 American Society of Clinical Oncology Annual Meeting.
No Survival Gains Seen with Nimotuzumab in Glioblastoma but More Study Warranted in Patients with MGMT Nonmethylated Glioblastoma
Nimotuzumab does not improve survival among newly diagnosed glioblastoma patients when added to standard temozolomide chemoradiotherapy, but warrants further study among patients with MGMT nonmethylated glioblastoma, according to a randomized multicenter phase 3 study reported at the 2012 American Society of Clinical Oncology Annual Meeting.
Probability of Long-Term Glioblastoma Survival Assessed
In glioblastoma, surviving for two years linked to favorable conditional probability of survival.
Health-Related QoL Evaluated for Children With Brain Tumors
Patient and parent assessments correlate well; affected by disease type and treatment intensity.
Potential New Drug Targets for Glioblastoma Found
For this study, the authors aimed to determine the precise role of NKCC1 in the invasiveness of human primary glioma cells in vitro and in vivo.
Surgery Alone is Sufficient for Children with Low-Risk Neuroblastoma
The primary study objective was to demonstrate that surgery alone would achieve 3-year overall survival ≥95% for patients with asymptomatic International Neuroblastoma Staging System stages 2a and 2b neuroblastoma, the investigators noted.
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