Addition of Atezolizumab to Chemo May Not Increase Treatment Burden
The addition of atezolizumab to standard chemotherapy does not appear to increase the treatment burden in patients with extensive-stage small-cell lung cancer.
Chemotherapy
OS Benefit Seen for Disease Downstaging With Neoadjuvant Chemotherapy vs Transurethral Resection in Muscle-Invasive Bladder Cancer
Two approaches to downstaging muscle-invasive bladder cancer prior to radical cystectomy include neoadjuvant chemotherapy and transurethral resection.
Addition of PEGPH20 to Frontline Chemotherapy Did Not Improve Clinical Outcomes in Pancreatic Cancer Subgroup
Pegvorhyaluronidase alfa is an enzyme that breaks down hyaluronan, thought to be a contributor to the structure of the tumor microenvironment in some pancreatic cancers.
Avatrombopag Designated Orphan Drug for Chemo-Induced Thrombocytopenia
The FDA has granted Orphan Drug designation to avatrombopag for the potential treatment of chemotherapy-induced thrombocytopenia, a complication that may lead to chemotherapy dose delays and regimen changes.
Cardiac Resynchronization Therapy Associated With Substantial Increase in LVEF in Patients With Chemotherapy-Induced Cardiomyopathy
Cardio-oncology is an emerging field focusing on the detection, monitoring, and treatment of cardiac dysfunction related to systemic or radiation therapy.
Adding Trastuzumab to Chemotherapy Yields No Benefit for HER2-Low Disease
The addition of trastuzumab to adjuvant chemotherapy did not improve outcomes for patients with HER2-low invasive breast cancer, a phase 3 randomized trial showed.
Toxicity Similar, But Overall Survival Poor in Cetuximab vs Cisplatin for HPV-Positive Oropharyngeal Cancer
In a randomized phase 3 trial, researchers sought to determine if cetuximab-based chemoradiotherapy could be a less-toxic alternative to cisplatin-based chemoradiotherapy in patients with HPV-positive oropharyngeal cancer.
Cinvanti Single-Dose Regimen Approved for Patients Receiving Moderately Emetogenic Chemotherapy
Cinvanti injectable emulsion can be administered as a 2-minute intravenous injection or 30-minute intravenous infusion.
Pathologists Need Better Reporting Guidelines for Postneoadjuvant Chemotherapy Specimens
Measuring a tumor’s response to neoadjuvant chemotherapy can be prognostic, providing important clues about a patient’s likely outcome following treatment.
Reading, Literacy Levels of Chemotherapy Educational Materials for Women With Breast Cancer Are Not Optimal
An evaluation of patient education materials on chemotherapy for breast cancer revealed that many do not meet NIH recommendations.
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