A New Look at the Dose-Response Relationship in Phase 1 Oncology Trials
The new generation of cancer drugs behave quite differently than cytotoxic therapies, and that may mean phase 1 trials need to be updated.
Diagnosis & Disease Information
Aromatherapy With Peppermint Essential Oil May Help Alleviate Nausea Associated With Chemotherapy
A randomized study determined the efficacy of adding peppermint essential oil to a cool wash cloth to ease nausea associated with chemotherapy.
DNA Repair Gene-Related CHIP Is a Marker for Worse Outcomes in Patients With Lymphoma
Clonal hematopoiesis of indeterminate origin has been defined as the presence of somatic mutations in hematopoietic stem cells at a variant gene frequency of more than 2%.
Pembrolizumab Shows Long-Term Advantage Over Chemotherapy in NSCLC
Updated data from KEYNOTE-010 showed superior outcomes for pembrolizumab compared with docetaxel in patients with PD-L1‒expressing advanced NSCLC.
Addition of Immunotherapy to Standard Neoadjuvant Chemotherapy Yields Promising Results in HER2-Negative Breast Cancer
The adaptive design of the I-SPY2 study allowed for the rapid evaluation of novel drugs in combination with neoadjuvant chemotherapy (NAC) compared with NAC alone.
BEGEV Salvage Regimen Linked to High Complete Remission Rates
5-year results from that a study on BEGV have confirmed its benefits in classical Hodgkin lymphoma.
Addition of Atezolizumab to Chemo May Not Increase Treatment Burden
The addition of atezolizumab to standard chemotherapy does not appear to increase the treatment burden in patients with extensive-stage small-cell lung cancer.
OS Benefit Seen for Disease Downstaging With Neoadjuvant Chemotherapy vs Transurethral Resection in Muscle-Invasive Bladder Cancer
Two approaches to downstaging muscle-invasive bladder cancer prior to radical cystectomy include neoadjuvant chemotherapy and transurethral resection.
Addition of PEGPH20 to Frontline Chemotherapy Did Not Improve Clinical Outcomes in Pancreatic Cancer Subgroup
Pegvorhyaluronidase alfa is an enzyme that breaks down hyaluronan, thought to be a contributor to the structure of the tumor microenvironment in some pancreatic cancers.
Avatrombopag Designated Orphan Drug for Chemo-Induced Thrombocytopenia
The FDA has granted Orphan Drug designation to avatrombopag for the potential treatment of chemotherapy-induced thrombocytopenia, a complication that may lead to chemotherapy dose delays and regimen changes.
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