Ribociclib Shown to Penetrate the Blood-Brain Barrier in Glioblastoma
A phase 0 study of ribociclib in patients with recurrent glioblastoma seeks to inform the feasibility of the use of CDK 4/6 inhibitors for deadly brain tumors.
Diagnosis & Disease Information
Treatment Reduction in Intermediate-Risk Neuroblastoma Deemed Successful
For specific subsets of patients with intermediate-risk neuroblastoma, an algorithm successfully reduced treatment while maintaining survival outcomes.
Outcomes Poor Years After Radiation for Pediatric Glioma Survivors
Survivors of childhood low-grade gliomas treated with radiotherapy have poorer neuropsychological and socioeconomic-status (SES) outcomes.
LIBRETTO-121: A Phase 1/2 Trial Investigating LOXO-292 in Pediatric Patients With Advanced Solid or Primary CNS Tumors
A primary outcome measure for phase 1 of the trial is determining the safety of oral LOXO-292.
Computer-Assisted Diagnosis Aids Detection of Glioma Growth
Computer-assisted diagnosis (CAD) can help physicians detect growth of low-grade gliomas.
Entrectinib Shows Activity in Pediatric Brain Tumors and Other Solid Tumors
Entrectinib showed activity and appeared to be safe in pediatric patients with recurrent or refractory solid tumors harboring NTRK1/2/3, ROS1, or ALK aberrations.
Phase 3 Study of Investigative Glioblastoma Tx Halted
AbbVie has halted enrollment in all ongoing studies of depatuxizumab mafodotin, after an Independent Data Monitoring Committee (IDMC) recommended a phase 3 study of the treatment be stopped due to a lack of survival benefit.
Immunotherapy in Glioblastoma: Peaks and Pits
New studies in glioblastoma highlight how PD-1 inhibitors could simultaneously prompt an immune response and steer the selection of tumor clones that evade immune recognition.
Liquid Biopsy of Cerebrospinal Fluid Provides Genomic Info on Brain Tumors
Clinical application of cerebrospinal fluid ctDNA analysis remains unclear.
Proteomics Study Reveals New Medulloblastoma Subtypes and Potential Novel Treatment Targets
Genomic and proteomic studies of medulloblastoma samples helped researchers characterize new cancer subtypes and targets.
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