Colorectal Cancer Pathogenesis May Be Driven by Alterations in MACROD2
The appearance of structural variants in MACROD2, culled from sequencing data from patients with colorectal cancer, may be a hallmark of CRC pathogenesis.
Colorectal Cancer
Pertuzumab Plus Trastuzumab in HER2-Amplified Metastatic Colorectal Cancer: Evidence For Promising Activity
Most patients with HER2-amplified colorectal cancer who achieved a response to pertuzumab plus trastuzumab had disease characterized as KRAS wild-type.
Vitiligo May Be Associated With Reduced Risk of Internal Cancer
Reductions in the risk of cancer were more pronounced in men and younger patients with vitiligo.
Possible Association Between Circulating Vitamin D Levels and Risk of CRC in Women
Higher circulating levels of 25(OH)D were also inversely associated with BRAF V600E-mutant colorectal cancer.
Distinct Clinical and Molecular Features Linked to Early-Onset Colorectal Cancer
Some patients with colorectal cancer are more likely to have disease characterized by a high frequency of mutations, microsatellite instability, and strong immune activation.
Gastrointestinal Cancers, Gastrointestinal Cancers News, General Oncology, Lung Cancer, Lung Cancer News
A Growing Focus on Rare Cancers in Phase I Trials
This study was presented at the 2019 International Congress on Targeted Anticancer Therapies (TAT) in Paris, France, from February 25-27, 2019. Dr Jun Sato of the National Cancer Center Hospital, Japan is the lead author of this study.1 Results from a retrospective study evaluating the focus of early-phase clinical trials of investigational drug candidates in…
The Incidence of Some Obesity-Related Cancers Is Increasing Among Young Adults
Obesity in childhood and adolescence may be related to the disproportionate rise in certain obesity-related cancers in younger adults, according to authors.
Aspirin and Liver, Ovarian Cancers
This fact sheet evaluates the data that suggest that aspirin can reduce the risk of liver and ovarian cancers.
Surgical Practices May Explain International Survival Differences in Cancer Treatment
Overall, patient survival was not associated with surgical technique.
Patients Uncomfortable Stopping Colorectal Cancer Screening Despite Low Value
Some patients may not be comfortable discontinuing colorectal cancer screening despite minimal benefit associated with the testing.
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