Adding Cixutumumab to Paclitaxel Does Not Improve Outcomes in Esophageal/GEJ Cancer
In metastatic esophageal/gastroesophageal junction cancer, the addition of cixutumumab to paclitaxel does not improve outcomes vs paclitaxel alone.
Diagnosis & Disease Information
BMI Over Time Tied to Risk of CRC and Other GI Cancers
Patients who are overweight or obese in early, middle, or late adulthood may have an increased risk of gastrointestinal cancers, a study suggests.
Neoadjuvant Chemoimmunotherapy Deemed Safe, Effective in Esophageal Cancer
Neoadjuvant chemotherapy combined with an immune checkpoint inhibitor is safe and effective in patients with resectable esophageal cancer, a real-world study suggests.
Sex Hormones Linked to Risk of Gastrointestinal Cancers
Higher levels of certain sex hormones are associated with an increased risk of some gastrointestinal cancers, a meta-analysis suggests.
Adagrasib Shows Activity in Hard-to-Treat KRAS-Mutated Solid Tumors
Adagrasib produced responses in a phase 1/2 trial of patients with heavily pretreated, KRAS G12C-mutated solid tumors.
Frontline Tislelizumab Prolongs Survival in Advanced Esophageal Cancer
Adding tislelizumab to platinum-based chemotherapy improves outcomes in patients with treatment-naïve, advanced esophageal cancer, a phase 3 study suggests.
Esophageal Cancer Incidence on the Rise, Mortality on the Decline
The incidence of esophageal cancer increased significantly from 2005 to 2019, but the mortality rate decreased.
Zolbetuximab Plus Chemo Deemed New Standard Care for Gastric/GEJ Cancer
Adding zolbetuximab to chemotherapy improves survival outcomes in patients with unresectable or metastatic gastric/GEJ cancer, a study suggests.
Frontline Pembrolizumab Improves PFS, OS in HER2- Gastric/GEJ Cancers
Adding pembrolizumab to frontline chemotherapy improves outcomes in patients with HER2-negative, advanced gastric or GEJ cancers, a phase 3 trial suggests.
Esophageal, Gastric Cancer Risks Reduced With Bariatric Surgery for Obesity
The use of bariatric surgery in patients with severe obesity is associated with a reduced incidence of esophageal and gastric cancers.
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