Possible Association Between Circulating Vitamin D Levels and Risk of CRC in Women
Higher circulating levels of 25(OH)D were also inversely associated with BRAF V600E-mutant colorectal cancer.
Gastrointestinal Cancer
Distinct Clinical and Molecular Features Linked to Early-Onset Colorectal Cancer
Some patients with colorectal cancer are more likely to have disease characterized by a high frequency of mutations, microsatellite instability, and strong immune activation.
Predicting PD-1/PD-L1 Immunotherapy Responses
Finding biomarkers that can broadly and reliably predict immunotherapy outcomes for patients with cancer remains an elusive “holy grail,” said Dr Ott.
Bladder Cancer, Bone Cancer, Brain Cancer, Breast Cancer, Cancer Topics, Chronic Lymphocytic Leukemia, Chronic Myeloid Leukemia, Endocrine Cancer, Gastrointestinal Cancers, General Oncology, Gynecologic Cancer, Head and Neck Cancer, Hematologic Cancers, Lung Cancer, Lymphoma, Multiple Myeloma, Pancreatic Cancer, Pediatric Cancer, Prostate Cancer, Renal Cell Carcinoma, Sarcoma, Skin Cancer, Urologic Cancers
Thawing Frozen Cancer Drug Labels
As medical care rapidly evolves, there’s really no debate over the potential for drug labels to become outdated, particularly in the high stakes world of cancer treatment. The question is how best to ameliorate the problem, while still protecting the process from financial and other conflicts. Off-label prescribing of cancer drugs is common, occurring 30%…
Differences in the Diagnosis, Management, and Outcomes of Hispanic Patients With Gastric Cancer Revealed
A retrospective study of patients with gastric cancer in the United States showed differences in patient- and disease-related characteristics, as well as different frequencies of staging laparoscopy, treatment/surgical approaches, and specific clinical outcomes, for those of Hispanic compared with non-Hispanic ethnicity. This study was published in the Journal of Surgical Oncology. In the US, the incidence of gastric…
Lonsurf Gains Metastatic Gastric Cancer Indication
The Food and Drug Administration has approved Lonsurf (trifluridine and tipiracil; Taiho Oncology) for the treatment of adult patients with metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma previously treated with at least 2 prior lines of chemotherapy that included a fluoropyrimidine, a platinum, either a taxane or irinotecan, and if appropriate, HER2/neu-targeted therapy. The approval was based…
Gastrointestinal Cancers, Gastrointestinal Cancers News, General Oncology, Lung Cancer, Lung Cancer News
A Growing Focus on Rare Cancers in Phase I Trials
This study was presented at the 2019 International Congress on Targeted Anticancer Therapies (TAT) in Paris, France, from February 25-27, 2019. Dr Jun Sato of the National Cancer Center Hospital, Japan is the lead author of this study.1 Results from a retrospective study evaluating the focus of early-phase clinical trials of investigational drug candidates in…
Treatment Guidelines in Cancer: Assessing Industry Influence on Recommendations
Concerns about conflict of interest as it relates to prescribing may never go away, some say, as long as drug companies offer doctors money for consulting and personal services.
Opinion: Understanding the FDA’s Take on Cannabidiol
In a statement announcing a newly created partnership, the Botanical Safety Consortium, FDA Commissioner Scott Gottlieb made no mention of cannabidiol.
High IDO1 Tumor Expression May Predict Poor Overall Survival in Patients With Anal Cancer
High tumor expression of IDO1 may identify whether a patient is likely to respond to immunotherapy, according to study authors.
