Clinical Trials for Cancer Therapies Lack Data on Patients With Cardiovascular Disease
While 1 in 3 trials on cancer treatment excluded patients with cardiovascular disease, definitions and reasoning for exclusion were not well documented.
General Oncology
Human Germline Editing: Call for a Moratorium and Creation of an International Governance Framework
The authors of this statement on human germline editing distinguished “genetic correction” from “genetic enhancement.”
Phytochemicals and Cancer
This fact sheet describes phytochemicals and the rationale behind their potential use as a chemopreventive.
Possible Association Between Circulating Vitamin D Levels and Risk of CRC in Women
Higher circulating levels of 25(OH)D were also inversely associated with BRAF V600E-mutant colorectal cancer.
The Downstream Effect of Misrepresented Clinical Trial Data
Data quality issues borne out in clinical trials don’t always reach peer reviewers, and as a result, may not reach prescribers, either.
Variant Calling Best Practices Benefit the Cancer Diagnostic Community
Improvements in the detection and evaluation of variants may help researchers uncover novel mutations of clinical significance.
First Cancer Immunotherapy Regimen Approved for Breast Cancer Treatment
The Food and Drug Administration (FDA) has granted accelerated approval to Tecentriq (atezolizumab; Genentech) in combination with Abraxane.
Coronary Calcification an Underused CV Risk Marker Following Cancer Treatment
Despite its availability as a risk marker for cardiovascular disease, action is rarely taken to address coronary artery calcification among those who have been treated for cancer with potentially cardiotoxic regimens.
CRISPR–Cas9 Gets a Rebrand: Meet Cas9–gRNA
Dr Porteus identified 14 past or ongoing trials in genome editing using zinc finger nucleases, 8 involving TALENs, and 12 involving CRISPR–Cas9.
Chemobrain: Experts Weigh in on Very Real — and Growing — Problem
Major advances in cancer treatment in recent decades have allowed patient survival rates to increase.
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