Presence of Allergy Biomarker Decreases Risk of Brain Cancer
When the interval between testing positive for total IgE and diagnosis of glioma was at least 20 years, there was a decreased risk of developing the disease.
Diagnosis & Disease Information
Cancer ‘Stem Cells’ Identified in Different Tumors
Three studies show small population of cells able to propagate tumors, support stem cell hypothesis.
A Novel Approach to Brain Tumor Therapy
Advisory Board member Tara Morrison, MD, a renowned expert in the treatment of brain cancer, reviews a novel brain tumor therapy.
No Survival Gains Seen with Nimotuzumab in Glioblastoma but More Study Warranted in Patients with MGMT Nonmethylated Glioblastoma
Nimotuzumab does not improve survival among newly diagnosed glioblastoma patients when added to standard temozolomide chemoradiotherapy, but warrants further study among patients with MGMT nonmethylated glioblastoma, according to a randomized multicenter phase 3 study reported at the 2012 American Society of Clinical Oncology Annual Meeting.
Probability of Long-Term Glioblastoma Survival Assessed
In glioblastoma, surviving for two years linked to favorable conditional probability of survival.
Potential New Drug Targets for Glioblastoma Found
For this study, the authors aimed to determine the precise role of NKCC1 in the invasiveness of human primary glioma cells in vitro and in vivo.
Researchers Delineate Brain Tumor Margins Using New Imaging Tool
Collaboration between researchers from several major medical institutions has led to the development of a new imaging tool for detecting brain tumors.
AANS: Vaccine Improves Survival in Glioblastoma Multiforme
Phase 2 study shows HSPPC-96 vaccine well tolerated; ups post-op survival in recurrent GBM.
Genetic Mutations Found Unique to Aggressive Pediatric Gliomas
Whole-genome sequencing of DNA from seven children with diffuse intrinsic pontine glioma (DIPG) and matched germline tissue and targeted sequencing of an additional 43 DIPGs found 78% of tumors had mutations encoding somatic histone H3 alterations, a study reported in Nature Genetics online January 29.
A20 E3 Ligase Inhibits TRAIL-Induced Apoptosis in Glioblastoma
Inhibiting A20 E3 ligase can overcome TNF-related apoptosis-inducing ligand (TRAIL) resistance in glioblastoma, according to a study published in Cancer Discovery OnlineFirst January 24, 2012.
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