Adding Nivolumab to Standard Care Does Not Improve Survival in Glioblastoma
The median PFS was 10.6 months in the nivolumab group and 10.3 months in the placebo group.
Diagnosis & Disease Information
Adding Marizomib to Standard Care Did Not Improve Survival in Newly Diagnosed Glioblastoma
There was no improvement in progression-free or overall survival with marizomib.
Subset of Glioblastoma Tumors Identified as Immunotherapy Candidate
Investigators performed immunohistochemistry on glioblastoma tumor samples in an effort to identify molecular subtypes associated with treatment sensitivities.
Autologous Dendritic Cell–Tumor Antigen Vaccine Shows Clinical Benefit in Glioblastoma
A vaccine consisting of autologous dendritic cells exposed to tumor antigens was well tolerated and showed clinical benefit among patients with glioblastoma.
Dexamethasone May Shorten Survival in Patients With Glioblastoma Treated With ICIs
Use of dexamethasone was associated with shorter survival in those with glioblastoma treated with a PD-1/PD-L1 inhibitor.
Phase 2 Trial Using IL-12 Gene Therapy for Glioblastoma Reaches Recruitment Target
A new approach combining inducible gene therapy and an anti–PD-1 shows promise in hard-to-treat brain tumors.
CheckMate 143: Nivolumab Produces Disappointing Results in Patients with Recurrent Glioblastoma
Nivolumab monotherapy fails to improve OS compared to bevacizumab in the treatment of recurrent glioblastoma.
Time to Radiotherapy After Glioblastoma Resection Affects Survival Outcomes
A large retrospective analysis demonstrated that a delay of 4 to 8 weeks for adjuvant radiotherapy following surgical resection of glioblastoma improved survival.
Peptide Derived From Scorpion Venom Helps CAR-T Cells Kill Gliomas in Preclinical Tests
Researchers have engineered CAR-T cells to express a peptide from scorpion venom to help them home to glioma cells.
Harnessing Key Elements of the Ebola Virus in Animal Models of Glioblastoma
A glycoprotein in Ebola called the mucin-like domain may be of interest in the development of an oncolytic for brain cancer.
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